LIFR Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells. Belongs to the type I cytokine receptor family. Type 2 subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: 5p13.1
Cellular Component:  integral component of plasma membrane; plasma membrane; receptor complex
Molecular Function:  ciliary neurotrophic factor receptor binding; growth factor binding; leukemia inhibitory factor receptor activity; protein binding
Biological Process:  cell surface receptor signaling pathway; ciliary neurotrophic factor-mediated signaling pathway; cytokine-mediated signaling pathway; leukemia inhibitory factor signaling pathway; oncostatin-M-mediated signaling pathway; positive regulation of cell proliferation; regulation of cytokine-mediated signaling pathway; response to cytokine
Disease: Stuve-wiedemann Syndrome
Reference #:  P42702 (UniProtKB)
Alt. Names/Synonyms: CD118; CD118 antigen; FLJ98106; FLJ99923; Leukemia inhibitory factor receptor; leukemia inhibitory factor receptor alpha; LIF receptor; LIF receptor alpha; LIF receptor subunit alpha; LIF-R; LIFR; SJS2; STWS; SWS
Gene Symbols: LIFR
Molecular weight: 123,743 Da
Basal Isoelectric point: 5.5  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein