tensin 3 May play a role in actin remodeling. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Seems to be involved in mammary cell migration. May be involved in cell migration and bone development. Expressed in umbilical vein endothelial cells, epithelial cells, and fibroblasts cells (at protein level). Highly expressed in thyroid, kidney and placenta. Low expression in heart, skeletal muscle, spleen, liver, and lung. Expressed in tumor endothelial cells. Expression seems to be down-regulated in thyroid tumor tissues and in anaplastic carcinomas. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of human Ortholog: 7p12.3
Cellular Component:  cytosol; focal adhesion
Molecular Function:  protein binding
Biological Process:  cell migration; lung alveolus development; positive regulation of cell proliferation
Reference #:  Q68CZ2 (UniProtKB)
Alt. Names/Synonyms: DKFZp686K12123; DKFZp686M1045; FLJ13732; FLJ35545; H_NH049I23.2; H_NH0549I23.2; MGC88434; TEM6; TENS1; TENS3; tensin 3; Tensin-3; tensin-like SH2 domain containing 1; tensin-like SH2 domain-containing 1; Tensin-like SH2 domain-containing protein 1; thyroid specific PTB domain protein; TNS3; TPP; Tumor endothelial marker 6
Gene Symbols: TNS3
Molecular weight: 155,266 Da
Basal Isoelectric point: 6.34  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling
Select Structure to View Below

tensin 3

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB