Rin1 iso2 Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis. Belongs to the RIN (Ras interaction/interference) family. Expressed in all tissues examined with high levels in brain, placenta and pancreas. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, Rab
Chromosomal Location of Human Ortholog: 11q13.2
Cellular Component:  cytoplasm; cytoskeleton; cytosol; dendrite; neuronal cell body; plasma membrane
Molecular Function:  GTPase activator activity; protein binding; Ras GTPase binding
Biological Process:  associative learning; endocytosis; memory; negative regulation of synaptic plasticity; positive regulation of GTPase activity; signal transduction
Reference #:  Q13671-2 (UniProtKB)
Alt. Names/Synonyms: Ras and Rab interactor 1; Ras inhibitor JC99; Ras interaction/interference protein 1; RIN1
Gene Symbols: RIN1
Molecular weight: 77,500 Da
Basal Isoelectric point: 6.78  Predict pI for various phosphorylation states
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Rin1 iso2

Protein Structure Not Found.

Cross-references to other databases:  cBioPortal  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene