Hrs iso2 Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation. Ubiquitous expression in adult and fetal tissues with higher expression in testis and peripheral blood leukocytes. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 17q25.3
Cellular Component:  cytosol; early endosome; early endosome membrane; endosome; ESCRT-0 complex; intracellular membrane-bounded organelle; lysosome; multivesicular body membrane
Molecular Function:  metal ion binding; protein binding; protein domain specific binding; ubiquitin-like protein ligase binding
Biological Process:  endosomal transport; macroautophagy; membrane invagination; membrane organization; multivesicular body assembly; negative regulation of angiogenesis; negative regulation of cell proliferation; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of JAK-STAT cascade; negative regulation of platelet-derived growth factor receptor signaling pathway; negative regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of exosomal secretion; positive regulation of gene expression; protein deubiquitination; protein localization to membrane; protein targeting to lysosome; regulation of MAP kinase activity; regulation of protein catabolic process; signal transduction
Reference #:  O14964-2 (UniProtKB)
Alt. Names/Synonyms: Hepatocyte growth factor-regulated tyrosine kinase substrate; HGS; Hrs; Hrs iso2; human growth factor-regulated tyrosine kinase substrate; Protein pp110
Gene Symbols: HGS
Molecular weight: 76,376 Da
Basal Isoelectric point: 5.62  Predict pI for various phosphorylation states
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Hrs iso2

Protein Structure Not Found.


Cross-references to other databases:  cBioPortal  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene