ING5 iso2 Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator. Inhibits cell growth, induces a delay in S-phase progression and enhances Fas-induced apoptosis in an INCA1-dependent manner. Belongs to the ING family. Down-regulated in bone marrow cells in acute myeloid leukemia patients as compared with normal bone marrow cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Tumor suppressor
Chromosomal Location of Human Ortholog: 2q37.3
Cellular Component:  MOZ/MORF histone acetyltransferase complex; nucleoplasm; nucleus
Molecular Function:  metal ion binding; methylated histone binding; protein binding
Biological Process:  DNA replication; histone H3 acetylation; negative regulation of cell proliferation; negative regulation of growth; positive regulation of apoptotic process; positive regulation of transcription, DNA-templated; protein acetylation; regulation of signal transduction by p53 class mediator
Reference #:  Q8WYH8-2 (UniProtKB)
Alt. Names/Synonyms: ING5; ING5 iso2; inhibitor of growth family member 5; Inhibitor of growth protein 5; p28ING5
Gene Symbols: ING5
Molecular weight: 25,932 Da
Basal Isoelectric point: 5.93  Predict pI for various phosphorylation states
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ING5 iso2

Protein Structure Not Found.


Cross-references to other databases:  cBioPortal  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein