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N-CoR1 iso2
Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation. Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression. The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver. Belongs to the N-CoR nuclear receptor corepressors family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor |
| Chromosomal Location of human Ortholog: 17p12-p11.2 |
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Cellular Component:
chromatin; cytosol; histone deacetylase complex; mitotic spindle; nucleoplasm; nucleus; transcription repressor complex
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Molecular Function:
histone deacetylase binding; nuclear receptor binding; nuclear thyroid hormone receptor binding; protein binding; RNA polymerase II-specific DNA-binding transcription factor binding; transcription cis-regulatory region binding; transcription corepressor activity
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Biological Process:
chromatin organization; locomotor rhythm; negative regulation of androgen receptor signaling pathway; negative regulation of DNA-templated transcription; negative regulation of fatty acid metabolic process; negative regulation of glycolytic process; negative regulation of JNK cascade; negative regulation of miRNA transcription; negative regulation of transcription by RNA polymerase II; spindle assembly
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Reference #:
O75376-2
(UniProtKB)
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Alt. Names/Synonyms: hN-CoR; KIAA1047; N-CoR; N-CoR1; N-CoR1 iso2; NCOR1; Nuclear receptor corepressor 1; PPP1R109; protein phosphatase 1, regulatory subunit 109; thyroid hormone- and retinoic acid receptor-associated corepressor 1; TRAC1
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Gene Symbols: NCOR1
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Molecular weight:
258,602 Da
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Basal Isoelectric point:
6.47
Predict pI for various phosphorylation states
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CST Pathways:
ErbB/HER Signaling
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Protein Acetylation
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