ASE-1 iso2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Isoform 1 is involved in UBTF-activated transcription, presumably at a step following PIC formation. Isoform 2 has been described as a component of preformed T-cell receptor (TCR) complex. Belongs to the eukaryotic RPA34 RNA polymerase subunit family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Nucleolus; Transcription initiation complex
Chromosomal Location of Human Ortholog: 19q13.32
Cellular Component:  chromosome; cytosol; fibrillar center; mitochondrion; nucleolus; nucleoplasm; nucleus; RNA polymerase I transcription factor complex
Molecular Function:  DNA-directed 5'-3' RNA polymerase activity
Biological Process:  positive regulation of gene expression, epigenetic; rRNA transcription; termination of RNA polymerase I transcription; transcription elongation from RNA polymerase I promoter; transcription initiation from RNA polymerase I promoter; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  O15446-2 (UniProtKB)
Alt. Names/Synonyms: A34.5; Antisense to ERCC-1 protein; ASE-1; ASE-1 iso2; ASE1; CAST; CD3-epsilon-associated protein; CD3E-associated protein; CD3EAP; DNA-directed RNA polymerase I subunit RPA34; PAF49; RNA polymerase I-associated factor PAF49
Gene Symbols: CD3EAP
Molecular weight: 55,172 Da
Basal Isoelectric point: 8.52  Predict pI for various phosphorylation states
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ASE-1 iso2

Protein Structure Not Found.

Cross-references to other databases:  cBioPortal  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein