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XRN2 iso2
Possesses 5'- Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily. Expressed in the spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes, heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Isoform 2 is expressed predominantly in peripheral blood leukocytes. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell development/differentiation; EC 3.1.13.-; Nucleolus; RNA processing; RNA-binding; Ribonuclease |
| Chromosomal Location of human Ortholog: 20p11.22 |
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Cellular Component:
aggresome; nucleolus; nucleoplasm; nucleus
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Molecular Function:
3'-5'-RNA exonuclease activity; 5'-3' exonuclease activity; 5'-3' RNA exonuclease activity; identical protein binding; metal ion binding; nuclease activity; protein binding; RNA binding; transcription termination site sequence-specific DNA binding
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Biological Process:
hippocampus development; mRNA processing; neuron differentiation; nuclear-transcribed mRNA catabolic process; retina development in camera-type eye; RNA catabolic process; RNA metabolic process; RNA processing; rRNA processing; spermatogenesis; termination of RNA polymerase II transcription
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Reference #:
Q9H0D6-2
(UniProtKB)
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Alt. Names/Synonyms: 5'-3' exoribonuclease 2; DHM1-like protein; DHP protein; XRN2; XRN2 iso2
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Gene Symbols: XRN2
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Molecular weight:
99,962 Da
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Basal Isoelectric point:
8.22
Predict pI for various phosphorylation states
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