ADORA3 Isoform 2: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Isoform 1: Plays a suppressive role in osteosarcoma malignancy by inhibiting NF-kappa-B activity. Belongs to the G-protein coupled receptor 1 family. Expressed in the lung and bone. Expressed at lower levels in osteosarcoma tissues (at protein level). 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 1p13.2
Cellular Component:  integral component of plasma membrane; plasma membrane
Molecular Function:  G protein-coupled adenosine receptor activity
Biological Process:  activation of adenylate cyclase activity; adenosine receptor signaling pathway; G protein-coupled receptor signaling pathway; inflammatory response; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of NF-kappaB transcription factor activity; regulation of heart contraction; response to wounding; signal transduction
Reference #:  P0DMS8 (UniProtKB)
Alt. Names/Synonyms: A3AR; AA3R; adenosine A3 receptor; Adenosine receptor A3; ADORA3
Gene Symbols: ADORA3
Molecular weight: 36,185 Da
Basal Isoelectric point: 9.11  Predict pI for various phosphorylation states
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ADORA3

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein