ADORA3 Isoform 2: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Isoform 1: Plays a suppressive role in osteosarcoma malignancy by inhibiting NF-kappa-B activity. Belongs to the G-protein coupled receptor 1 family. Expressed in the lung and bone. Expressed at lower levels in osteosarcoma tissues (at protein level). 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 2q34
Cellular Component:  integral component of membrane; integral component of plasma membrane; plasma membrane; presynaptic membrane; Schaffer collateral - CA1 synapse
Molecular Function:  G protein-coupled adenosine receptor activity
Biological Process:  adenosine receptor signaling pathway; G protein-coupled receptor signaling pathway; histamine secretion by mast cell; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of NF-kappaB transcription factor activity; positive regulation of calcium-mediated signaling; positive regulation of inflammatory response; positive regulation of leukocyte migration; positive regulation of mast cell degranulation; positive regulation of mucus secretion; positive regulation of phosphatidylinositol 3-kinase signaling; regulation of norepinephrine secretion; regulation of synaptic vesicle exocytosis
Reference #:  P28647 (UniProtKB)
Alt. Names/Synonyms: AA3R; adenosine A3 receptor; Adenosine receptor A3; Adora3; TGPCR1
Gene Symbols: Adora3
Molecular weight: 36,629 Da
Basal Isoelectric point: 9.35  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene