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axin 1 iso2
Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Ubiquitously expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Tumor suppressor |
| Chromosomal Location of human Ortholog: 16p13.3 |
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Cellular Component:
beta-catenin destruction complex; cell cortex; cell periphery; cytoplasm; cytoplasmic vesicle; cytosol; lateral plasma membrane; microtubule cytoskeleton; nucleus; perinuclear region of cytoplasm; plasma membrane; Wnt signalosome
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Molecular Function:
armadillo repeat domain binding; beta-catenin binding; enzyme binding; I-SMAD binding; identical protein binding; molecular adaptor activity; p53 binding; protein binding; protein homodimerization activity; protein kinase binding; protein self-association; R-SMAD binding; signaling adaptor activity; signaling receptor complex adaptor activity; SMAD binding; ubiquitin protein ligase binding
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Biological Process:
activation of protein kinase activity; apoptotic process; axial mesoderm formation; canonical Wnt signaling pathway; cell development; cytoplasmic microtubule organization; dorsal/ventral axis specification; genomic imprinting; head development; in utero embryonic development; negative regulation of canonical Wnt signaling pathway; negative regulation of fat cell differentiation; negative regulation of gene expression; negative regulation of protein metabolic process; negative regulation of transcription elongation by RNA polymerase II; nucleocytoplasmic transport; positive regulation of DNA-templated transcription; positive regulation of JNK cascade; positive regulation of JUN kinase activity; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-threonine phosphorylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein catabolic process; positive regulation of protein kinase activity; positive regulation of protein phosphorylation; positive regulation of protein ubiquitination; positive regulation of transforming growth factor beta receptor signaling pathway; positive regulation of ubiquitin-dependent protein catabolic process; positive regulation of ubiquitin-protein transferase activity; post-anal tail morphogenesis; proteasome-mediated ubiquitin-dependent protein catabolic process; protein polyubiquitination; protein-containing complex assembly; sensory perception of sound
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Reference #:
O15169-2
(UniProtKB)
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Alt. Names/Synonyms: AXIN; axin 1; axin 1 iso2; Axin-1; AXIN1; Axis inhibition protein 1; axis inhibitor 1; fused, mouse, homolog of; hAxin; PPP1R49; protein phosphatase 1, regulatory subunit 49
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Gene Symbols: AXIN1
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Molecular weight:
91,653 Da
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Basal Isoelectric point:
6.55
Predict pI for various phosphorylation states
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CST Pathways:
ESC Pluripotency and Differentiation
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Wnt/ß-Catenin Signaling
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