BMAL1 aryl hydrocarbon receptor nuclear translocator-like protein. A circadian regulatory protein and substrate of casein kinase I epsilon. Heterodimers bind to an E-box element (3'-CACGTG-5'), thereby activating transcription of PER1, and possibly of other circadian clock proteins. Seven splice isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Cellular Component:  chromatoid body; PML body; transcription factor complex
Molecular Function:  aryl hydrocarbon receptor binding; bHLH transcription factor binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; E-box binding; Hsp90 protein binding; protein heterodimerization activity; repressing transcription factor binding; RNA polymerase II distal enhancer sequence-specific DNA binding
Biological Process:  circadian regulation of gene expression; circadian rhythm; maternal process involved in parturition; negative regulation of cold-induced thermogenesis; negative regulation of fat cell differentiation; negative regulation of glucocorticoid receptor signaling pathway; negative regulation of TOR signaling; negative regulation of transcription, DNA-templated; oxidative stress-induced premature senescence; positive regulation of canonical Wnt signaling pathway; positive regulation of circadian rhythm; positive regulation of protein acetylation; positive regulation of skeletal muscle cell differentiation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; proteasome-mediated ubiquitin-dependent protein catabolic process; protein import into nucleus; regulation of cell cycle; regulation of cellular senescence; regulation of hair cycle; regulation of insulin secretion; regulation of neurogenesis; regulation of protein catabolic process; regulation of type B pancreatic cell development; response to redox state; spermatogenesis
Reference #:  Q9I8T7 (UniProtKB)
Alt. Names/Synonyms: ARNTL; aryl hydrocarbon receptor nuclear translocator-like; Aryl hydrocarbon receptor nuclear translocator-like protein 1; BMAL1
Gene Symbols: ARNTL
Molecular weight: 69,437 Da
Basal Isoelectric point: 6.09  Predict pI for various phosphorylation states
Select Structure to View Below

BMAL1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene