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BMAL1
a transcriptional activator protein that forms a core component of the circadian clock. An aryl hydrocarbon receptor nuclear translocator-like protein. A circadian regulatory protein and substrate of casein kinase I epsilon. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. Heterodimers bind to an E-box element (3'-CACGTG-5'), thereby activating transcription of PER1, and possibly of other circadian clock proteins. Nine splice isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Transcription factor |
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Cellular Component:
aryl hydrocarbon receptor complex; cytoplasm; nucleus; PML body; transcription regulator complex
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Molecular Function:
DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; protein dimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding
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Biological Process:
circadian rhythm; positive regulation of DNA-templated transcription; positive regulation of protein acetylation; regulation of transcription by RNA polymerase II; response to redox state
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Reference #:
Q9I8T7
(UniProtKB)
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Alt. Names/Synonyms: ARNTL; aryl hydrocarbon receptor nuclear translocator-like; Aryl hydrocarbon receptor nuclear translocator-like protein 1; Basic helix-loop-helix ARNT-like protein 1; BMAL1
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Gene Symbols: BMAL1
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Molecular weight:
69,437 Da
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Basal Isoelectric point:
6.09
Predict pI for various phosphorylation states
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