CDC25B iso2
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity. Belongs to the MPI phosphatase family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: EC 3.1.3.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Protein phosphatase, dual-specificity |
Chromosomal Location of human Ortholog: 20p13 |
Cellular Component:
centrosome; cytoplasm; cytosol; nucleoplasm; nucleus; spindle pole
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Molecular Function:
phosphoprotein phosphatase activity; protein binding; protein kinase binding; protein tyrosine phosphatase activity
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Biological Process:
cell division; female meiosis I; G2/M transition of mitotic cell cycle; mitotic cell cycle; oocyte maturation; positive regulation of cell population proliferation; positive regulation of cytokinesis; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of G2/MI transition of meiotic cell cycle; positive regulation of mitotic cell cycle; positive regulation of protein kinase activity; protein dephosphorylation; protein phosphorylation
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Reference #:
P30305-2
(UniProtKB)
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Alt. Names/Synonyms: CDC25B; CDC25B iso2; CDC25HU2; cell division cycle 25 homolog B (S. pombe); cell division cycle 25B; Dual specificity phosphatase Cdc25B; M-phase inducer phosphatase 2; MPIP2
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Gene Symbols: CDC25B
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Molecular weight:
63,443 Da
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Basal Isoelectric point:
5.92
Predict pI for various phosphorylation states
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