CNGA1 Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA1 subfamily. Rod cells in the retina. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, cation; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of mouse Ortholog: 5 C3.2|5 38.44 cM
Cellular Component:  intracellular cyclic nucleotide activated cation channel complex; membrane; photoreceptor outer segment; photoreceptor outer segment membrane; plasma membrane; terminal bouton
Molecular Function:  cGMP binding; intracellular cAMP-activated cation channel activity; intracellular cGMP-activated cation channel activity; monoatomic ion channel activity; nucleotide binding; protein-containing complex binding
Biological Process:  membrane depolarization; monoatomic cation transmembrane transport; monoatomic ion transport; regulation of cytosolic calcium ion concentration; response to stimulus; transmembrane transport; visual perception
Reference #:  P29974 (UniProtKB)
Alt. Names/Synonyms: cGMP-gated cation channel alpha-1; Cnc; Cncg; Cncg1; CNG channel alpha-1; CNG-1; CNG1; Cnga1; cyclic nucleotide gated channel alpha 1; cyclic nucleotide gated channel, cGMP gated; Cyclic nucleotide-gated cation channel 1; Cyclic nucleotide-gated channel alpha-1; Cyclic nucleotide-gated channel, photoreceptor; Rod photoreceptor cGMP-gated channel subunit alpha
Gene Symbols: Cnga1
Molecular weight: 79,460 Da
Basal Isoelectric point: 7.45  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein