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CNGA1
Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA1 subfamily. Rod cells in the retina. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Channel, cation; Membrane protein, integral; Membrane protein, multi-pass |
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Cellular Component:
photoreceptor outer segment; transmembrane transporter complex
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Molecular Function:
cGMP binding; intracellular cGMP-activated cation channel activity
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Biological Process:
monoatomic cation transport; response to stimulus; visual perception
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Reference #:
Q00194
(UniProtKB)
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Alt. Names/Synonyms: BOS_6619; cGMP-gated cation channel alpha-1; CNCG; CNCG1; CNG channel alpha 1; CNG-1; CNG1; CNGA1; Cyclic nucleotide gated channel alpha 1; Cyclic nucleotide gated channel, photoreceptor; Cyclic-nucleotide-gated cation channel 1; Rod photoreceptor cGMP-gated channel alpha subunit
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Gene Symbols: CNGA1
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Molecular weight:
79,602 Da
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Basal Isoelectric point:
6.69
Predict pI for various phosphorylation states
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