CNGA1 Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA1 subfamily. Rod cells in the retina. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, cation; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of human Ortholog: 4p12
Cellular Component:  intracellular cyclic nucleotide activated cation channel complex; photoreceptor outer segment membrane; plasma membrane
Molecular Function:  cGMP binding; intracellular cAMP-activated cation channel activity; intracellular cGMP-activated cation channel activity; protein binding; protein-containing complex binding
Biological Process:  cation transmembrane transport; response to stimulus; visual perception
Disease: Retinitis Pigmentosa; Retinitis Pigmentosa 49
Reference #:  P29973 (UniProtKB)
Alt. Names/Synonyms: cGMP-gated cation channel alpha-1; CNCG; CNCG1; CNG channel alpha-1; CNG-1; CNG1; CNGA1; cyclic nucleotide gated channel alpha 1; cyclic nucleotide gated channel subunit alpha 1; Cyclic nucleotide-gated cation channel 1; Cyclic nucleotide-gated channel alpha-1; Cyclic nucleotide-gated channel, photoreceptor; interleukin-1 homologue; RCNC1; RCNCa; RCNCalpha; Rod photoreceptor cGMP-gated channel subunit alpha; RP49
Gene Symbols: CNGA1
Molecular weight: 79,126 Da
Basal Isoelectric point: 7.44  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein