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CNGA1
Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA1 subfamily. Rod cells in the retina. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Channel, cation; Membrane protein, integral; Membrane protein, multi-pass |
| Chromosomal Location of human Ortholog: 4p12 |
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Cellular Component:
intracellular cyclic nucleotide activated cation channel complex; photoreceptor outer segment membrane; plasma membrane
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Molecular Function:
cGMP binding; intracellular cAMP-activated cation channel activity; intracellular cGMP-activated cation channel activity; protein binding; protein-containing complex binding
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Biological Process:
cation transmembrane transport; response to stimulus; visual perception
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Disease: Retinitis Pigmentosa; Retinitis Pigmentosa 49
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Reference #:
P29973
(UniProtKB)
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Alt. Names/Synonyms: cGMP-gated cation channel alpha-1; CNCG; CNCG1; CNG channel alpha-1; CNG-1; CNG1; CNGA1; cyclic nucleotide gated channel alpha 1; cyclic nucleotide gated channel subunit alpha 1; Cyclic nucleotide-gated cation channel 1; Cyclic nucleotide-gated channel alpha-1; Cyclic nucleotide-gated channel, photoreceptor; interleukin-1 homologue; RCNC1; RCNCa; RCNCalpha; Rod photoreceptor cGMP-gated channel subunit alpha; RP49
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Gene Symbols: CNGA1
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Molecular weight:
79,126 Da
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Basal Isoelectric point:
7.44
Predict pI for various phosphorylation states
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