NEU3 Plays a role in modulating the ganglioside content of the lipid bilayer at the level of membrane-bound sialyl glycoconjugates. Belongs to the glycosyl hydrolase 33 family. Highly expressed in skeletal muscle, testis, adrenal gland and thymus, followed by pancreas, liver, heart and thymus. Weakly expressed in kidney, placenta, brain and lung. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Glycan Metabolism - other glycan degradation; Hydrolase; Lipid Metabolism - sphingolipid
Chromosomal Location of human Ortholog: 11q13.4
Cellular Component:  plasma membrane
Molecular Function:  alpha-sialidase activity; exo-alpha-(2->3)-sialidase activity; exo-alpha-(2->6)-sialidase activity; exo-alpha-(2->8)-sialidase activity; exo-alpha-sialidase activity
Biological Process:  carbohydrate metabolic process; ganglioside catabolic process; glycosphingolipid metabolic process; oligosaccharide catabolic process
Reference #:  Q9UQ49 (UniProtKB)
Alt. Names/Synonyms: FLJ12388; Ganglioside sialidase; Membrane sialidase; N-acetyl-alpha-neuraminidase 3; NEU3; NEUR3; neuraminidase 3; SIAL3; sialidase 3 (membrane sialidase); Sialidase-3
Gene Symbols: NEU3
Molecular weight: 48,252 Da
Basal Isoelectric point: 6.78  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene