CNGB1 Subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP. Isoform GARP2 is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties: it is a regulator of spontaneous activation of rod PDE6, thereby serving to lower rod photoreceptor 'dark noise' and allowing these sensory cells to operate at the single photon detection limit. Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGB1 subfamily. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, cation; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 19p13
Cellular Component:  intracellular cyclic nucleotide activated cation channel complex; membrane; photoreceptor outer segment; plasma membrane; terminal bouton; transmembrane transporter complex
Molecular Function:  cGMP binding; cyclic nucleotide-gated ion channel activity; intracellular cAMP-activated cation channel activity; intracellular cGMP-activated cation channel activity; intracellular cyclic nucleotide activated cation channel activity
Biological Process:  cation transmembrane transport; cation transport; detection of light stimulus involved in visual perception; photoreceptor cell maintenance; photoreceptor cell outer segment organization; phototransduction; protein heterotetramerization; protein localization to organelle; regulation of cytosolic calcium ion concentration; retina homeostasis; sensory perception of smell; visual perception
Reference #:  O35788 (UniProtKB)
Alt. Names/Synonyms: Cngb1; cyclic nucleotide gated channel beta 1; Cyclic nucleotide-gated cation channel alpha subunit; Cyclic nucleotide-gated channel beta subunit; cyclic nucleotide-gated channel beta subunit 1; Gm1959
Gene Symbols: Cngb1
Molecular weight: 151,047 Da
Basal Isoelectric point: 4.44  Predict pI for various phosphorylation states
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CNGB1

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene