CNGB1
Subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP. Isoform GARP2 is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties: it is a regulator of spontaneous activation of rod PDE6, thereby serving to lower rod photoreceptor 'dark noise' and allowing these sensory cells to operate at the single photon detection limit. Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGB1 subfamily. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Channel, cation; Membrane protein, integral; Membrane protein, multi-pass |
Chromosomal Location of human Ortholog: 16q21 |
Cellular Component:
ciliary membrane; Golgi-associated vesicle membrane; intracellular cyclic nucleotide activated cation channel complex; photoreceptor outer segment; plasma membrane; terminal bouton; transmembrane transporter complex
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Molecular Function:
cAMP binding; cGMP binding; intracellular cAMP-activated cation channel activity; intracellular cGMP-activated cation channel activity; ligand-gated monoatomic ion channel activity; protein binding; protein-containing complex binding
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Biological Process:
detection of chemical stimulus involved in sensory perception of smell; detection of light stimulus involved in visual perception; ion channel modulating, G protein-coupled receptor signaling pathway; membrane depolarization; monoatomic cation transmembrane transport; monoatomic cation transport; olfactory nerve maturation; photoreceptor cell maintenance; photoreceptor cell outer segment organization; phototransduction; positive regulation of gene expression; protein localization to organelle; regulation of cytosolic calcium ion concentration; response to odorant; retina homeostasis; visual perception
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Disease: Retinitis Pigmentosa 45
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Reference #:
Q14028
(UniProtKB)
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Alt. Names/Synonyms: CNCG2; CNCG3L; CNCG4; CNG channel 4; CNG channel beta-1; CNG-4; CNG4; CNGB1; CNGB1B; cyclic nucleotide gated channel (photoreceptor), cGMP gated 3 (gamma)-like; cyclic nucleotide gated channel beta 1; cyclic nucleotide gated channel subunit beta 1; Cyclic nucleotide-gated cation channel 4; Cyclic nucleotide-gated cation channel beta-1; Cyclic nucleotide-gated cation channel gamma; Cyclic nucleotide-gated cation channel modulatory subunit; Cyclic nucleotide-gated channel beta-1; GAR1; GARP; GARP2; Glutamic acid-rich protein; glutamic-acid-rich protein; RCNC2; RCNCb; RCNCbeta; RP45
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Gene Symbols: CNGB1
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Molecular weight:
139,678 Da
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Basal Isoelectric point:
4.76
Predict pI for various phosphorylation states
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