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STAT5A
Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation. Belongs to the transcription factor STAT family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor |
| Chromosomal Location of Human Ortholog: 10q31 |
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Cellular Component:
cytoplasm; cytosol; nucleoplasm; nucleus
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Molecular Function:
DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; double-stranded DNA binding; phosphate ion binding; protein binding; RNA polymerase II proximal promoter sequence-specific DNA binding; sequence-specific DNA binding
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Biological Process:
cellular response to cytokine stimulus; cellular response to granulocyte macrophage colony-stimulating factor stimulus; cellular response to organic cyclic compound; cytokine-mediated signaling pathway; defense response; development of secondary female sexual characteristics; development of secondary male sexual characteristics; epithelial cell differentiation involved in prostate gland development; female pregnancy; JAK-STAT cascade; JAK-STAT cascade involved in growth hormone signaling pathway; lactation; lipid storage; luteinization; mammary gland development; mammary gland epithelium development; mammary gland involution; multicellular organismal reproductive process; natural killer cell differentiation; negative regulation of apoptotic process; negative regulation of erythrocyte differentiation; negative regulation of mast cell apoptotic process; peptidyl-tyrosine phosphorylation; Peyer's patch development; positive regulation of activated T cell proliferation; positive regulation of B cell differentiation; positive regulation of blood vessel endothelial cell migration; positive regulation of cell proliferation; positive regulation of endothelial cell proliferation; positive regulation of gamma-delta T cell differentiation; positive regulation of inflammatory response; positive regulation of interleukin-2 biosynthetic process; positive regulation of lymphocyte differentiation; positive regulation of mast cell differentiation; positive regulation of mast cell proliferation; positive regulation of mitotic cell cycle; positive regulation of multicellular organism growth; positive regulation of natural killer cell differentiation; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of transcription by RNA polymerase II; prostate gland epithelium morphogenesis; reelin-mediated signaling pathway; regulation of cell adhesion; regulation of cell proliferation; regulation of epithelial cell differentiation; regulation of multicellular organism growth; regulation of steroid metabolic process; regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; response to ethanol; response to nutrient levels; response to peptide hormone; T cell differentiation in thymus; T cell homeostasis; taurine metabolic process; transcription by RNA polymerase II
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Reference #:
Q62771
(UniProtKB)
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Alt. Names/Synonyms: Mammary gland factor; Mgf; signal transducer and activator of transcription 5; Signal transducer and activator of transcription 5A; STA5A; Stat5; Stat5a
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Gene Symbols: Stat5a
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Molecular weight:
90,833 Da
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Basal Isoelectric point:
5.97
Predict pI for various phosphorylation states
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CST Pathways:
ErbB/HER Signaling
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IL6 Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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