DRPLA Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation. Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats. Widely expressed in various tissues including heart, lung, kidney, ovary, testis, prostate, placenta, skeletal Low levels in the liver, thymus and leukocytes. In the adult brain, broadly expressed in amygdala, caudate nucleus, corpus callosum, hippocampus, hypothalamus, substantia nigra, subthalamic nucleus, and thalamus. High levels in fetal tissues, especially brain. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 4q42
Cellular Component:  cell junction; cell leading edge; cytoplasm; nuclear matrix; nucleoplasm; nucleus; perinuclear region of cytoplasm
Molecular Function:  DNA binding; JUN kinase binding; protein binding; protein domain specific binding; RNA polymerase II transcription factor binding; toxin activity; transcription coactivator activity; transcription corepressor activity
Biological Process:  cell migration; determination of adult lifespan; maintenance of cell polarity; male gonad development; multicellular organism growth; negative regulation of nucleic acid-templated transcription; negative regulation of transcription by RNA polymerase II; neuron apoptotic process; post-embryonic development; regulation of neuron differentiation; response to food; spermatogenesis; toxin metabolic process
Reference #:  P54258 (UniProtKB)
Alt. Names/Synonyms: Atn1; atrophin 1; Atrophin-1; dentatorubral pallidoluysian atrophy; Dentatorubral-pallidoluysian atrophy protein homolog; Drpla
Gene Symbols: Atn1
Molecular weight: 124,779 Da
Basal Isoelectric point: 8.97  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene