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NHERF
Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli. Involved in the regulation of phosphate reabsorption in the renal proximal tubules. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa. Detected in liver, kidney, pancreas, prostate, spleen, small intestine and placenta, in particular in the syncytiotrophoblast. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis |
| Chromosomal Location of human Ortholog: 17q25.1 |
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Cellular Component:
actin cytoskeleton; apical plasma membrane; brush border membrane; cell periphery; cytoplasm; endomembrane system; filopodium; membrane; microvillus; microvillus membrane; nucleus; perinuclear region of cytoplasm; plasma membrane protein complex; ruffle; sperm midpiece; stereocilium tip
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Molecular Function:
beta-2 adrenergic receptor binding; beta-catenin binding; channel activator activity; chloride channel regulator activity; dopamine receptor binding; gamma-aminobutyric acid transmembrane transporter activity; growth factor receptor binding; identical protein binding; myosin II binding; PDZ domain binding; phosphatase binding; protein binding; protein self-association; protein-containing complex binding; protein-membrane adaptor activity; signaling receptor binding; transmembrane transporter binding; type 2 metabotropic glutamate receptor binding; type 3 metabotropic glutamate receptor binding
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Biological Process:
actin cytoskeleton organization; adenylate cyclase-activating dopamine receptor signaling pathway; auditory receptor cell stereocilium organization; bile acid secretion; cerebrospinal fluid circulation; cilium organization; establishment of epithelial cell apical/basal polarity; establishment of Golgi localization; fibroblast migration; gamma-aminobutyric acid import; gland morphogenesis; glutathione transport; import across plasma membrane; intracellular phosphate ion homeostasis; maintenance of epithelial cell apical/basal polarity; microvillus assembly; morphogenesis of an epithelium; negative regulation of canonical Wnt signaling pathway; negative regulation of cell population proliferation; negative regulation of ERK1 and ERK2 cascade; negative regulation of fibroblast migration; negative regulation of mitotic cell cycle; negative regulation of phosphatidylinositol 3-kinase signaling; negative regulation of platelet-derived growth factor receptor signaling pathway; negative regulation of protein kinase B signaling; negative regulation of sodium:proton antiporter activity; nuclear migration; phospholipase C-activating dopamine receptor signaling pathway; plasma membrane organization; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of monoatomic ion transmembrane transport; protein localization to plasma membrane; protein-containing complex assembly; regulation of cell shape; regulation of cell size; regulation of protein kinase activity; regulation of renal phosphate excretion; renal absorption; renal phosphate ion absorption; renal sodium ion transport; sensory perception of sound; transport across blood-brain barrier; Wnt signaling pathway
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Disease: Nephrolithiasis/osteoporosis, Hypophosphatemic, 2
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Reference #:
O14745
(UniProtKB)
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Alt. Names/Synonyms: EBP50; ezrin-radixin-moesin binding phosphoprotein-50; Ezrin-radixin-moesin-binding phosphoprotein 50; Na(+)/H(+) exchange regulatory cofactor NHE-RF1; Na+/H+ exchange regulatory co-factor; NHERF; NHERF-1; NHERF1; NHRF1; NPHLOP2; Regulatory cofactor of Na(+)/H(+) exchanger; SLC9A3 regulator 1; SLC9A3R1; Sodium-hydrogen exchanger regulatory factor 1; sodium/hydrogen exchanger regulatory factor 1; solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulatory factor 1; solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1; Solute carrier family 9 isoform A3 regulatory factor 1; solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
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Gene Symbols: NHERF1
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Molecular weight:
38,868 Da
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Basal Isoelectric point:
5.55
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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