NHERF Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli. Involved in the regulation of phosphate reabsorption in the renal proximal tubules. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa. Detected in liver, kidney, pancreas, prostate, spleen, small intestine and placenta, in particular in the syncytiotrophoblast. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of human Ortholog: 17q25.1
Cellular Component:  actin cytoskeleton; apical plasma membrane; brush border membrane; cell periphery; cytoplasm; endomembrane system; filopodium; membrane; membrane raft; microvillus; microvillus membrane; perinuclear region of cytoplasm; ruffle; sperm midpiece; stereocilium tip
Molecular Function:  beta-2 adrenergic receptor binding; beta-catenin binding; chloride channel regulator activity; dopamine receptor binding; growth factor receptor binding; molecular adaptor activity; myosin II binding; PDZ domain binding; phosphatase binding; protein binding; protein N-terminus binding; protein self-association; protein-containing complex binding; signaling receptor binding
Biological Process:  actin cytoskeleton organization; adenylate cyclase-activating dopamine receptor signaling pathway; auditory receptor cell stereocilium organization; bile acid secretion; cellular phosphate ion homeostasis; establishment of epithelial cell apical/basal polarity; establishment of Golgi localization; gland morphogenesis; glutathione transport; microvillus assembly; negative regulation of canonical Wnt signaling pathway; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of ERK1 and ERK2 cascade; negative regulation of mitotic cell cycle; negative regulation of phosphatidylinositol 3-kinase signaling; negative regulation of platelet-derived growth factor receptor signaling pathway; negative regulation of protein kinase B signaling; negative regulation of sodium:proton antiporter activity; nuclear migration; phospholipase C-activating dopamine receptor signaling pathway; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of ion transmembrane transport; protein localization to plasma membrane; protein-containing complex assembly; regulation of cell shape; regulation of cell size; regulation of excretion; regulation of protein kinase activity; regulation of sodium:proton antiporter activity; renal absorption; renal phosphate ion absorption; renal sodium ion transport; sensory perception of sound; Wnt signaling pathway
Disease: Nephrolithiasis/osteoporosis, Hypophosphatemic, 2
Reference #:  O14745 (UniProtKB)
Alt. Names/Synonyms: EBP50; ezrin-radixin-moesin binding phosphoprotein-50; Ezrin-radixin-moesin-binding phosphoprotein 50; Na(+)/H(+) exchange regulatory cofactor NHE-RF1; Na+/H+ exchange regulatory co-factor; NHERF; NHERF-1; NHERF1; NHRF1; NPHLOP2; Regulatory cofactor of Na(+)/H(+) exchanger; SLC9A3 regulator 1; SLC9A3R1; Sodium-hydrogen exchanger regulatory factor 1; sodium/hydrogen exchanger regulatory factor 1; solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulatory factor 1; solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1; Solute carrier family 9 isoform A3 regulatory factor 1; solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
Gene Symbols: SLC9A3R1
Molecular weight: 38,868 Da
Basal Isoelectric point: 5.55  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene