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GRP58
Belongs to the protein disulfide isomerase family. Detected in the flagellum and head region of spermatozoa (at protein level). Note: This description may include information from UniProtKB.
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| Protein type: Apoptosis; Chaperone; EC 5.3.4.1; Endoplasmic reticulum; Isomerase; Phospholipase; Protease |
| Chromosomal Location of mouse Ortholog: 2 E5|2 60.38 cM |
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Cellular Component:
acrosomal vesicle; apical plasma membrane; cell surface; endoplasmic reticulum; endoplasmic reticulum lumen; extracellular region; extracellular space; MHC class I peptide loading complex; smooth endoplasmic reticulum; TAP complex; Tapasin-ERp57 complex
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Molecular Function:
identical protein binding; isomerase activity; MHC class I protein binding; peptidase activity; protein binding; protein disulfide isomerase activity; protein-disulfide reductase (glutathione) activity; protein-disulfide reductase activity
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Biological Process:
cellular response to interleukin-7; cellular response to vitamin D; extrinsic apoptotic signaling pathway; peptide antigen assembly with MHC class I protein complex; platelet aggregation; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of protein folding; protein folding; response to endoplasmic reticulum stress
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Reference #:
P27773
(UniProtKB)
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Alt. Names/Synonyms: 58 kDa glucose-regulated protein; 58 kDa microsomal protein; 58kDa; Disulfide isomerase ER-60; endoplasmic reticulum protein; Endoplasmic reticulum resident protein 57; Endoplasmic reticulum resident protein 60; ER protein 57; ER protein 60; Erp; ERp57; ERp60; ERp61; glucose regulated protein, 58 kDa; Grp; Grp58; OTTMUSP00000016318; p58; PDI; PDI-; PDI-Q2; Pdia3; phospholipase C, alpha; PI-PLC; PLC[a]; Plca; protein disulfide isomerase associated 3; Protein disulfide-isomerase A3
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Gene Symbols: Pdia3
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Molecular weight:
56,678 Da
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Basal Isoelectric point:
5.88
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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