GRP58 Belongs to the protein disulfide isomerase family. Detected in the flagellum and head region of spermatozoa (at protein level). Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Chaperone; EC; Endoplasmic reticulum; Isomerase; Phospholipase; Protease
Chromosomal Location of Human Ortholog: 3q35
Cellular Component:  acrosomal vesicle; apical plasma membrane; cell surface; cytoplasm; endoplasmic reticulum; endoplasmic reticulum lumen; extracellular region; extracellular space; melanosome; MHC class I peptide loading complex; mitochondrial intermembrane space; mitochondrion; nucleus; plasma membrane; smooth endoplasmic reticulum; TAP complex
Molecular Function:  identical protein binding; MHC class I protein binding; peptidase activity; peptide disulfide oxidoreductase activity; protein binding; protein disulfide isomerase activity; protein-disulfide reductase (glutathione) activity
Biological Process:  cell redox homeostasis; cellular response to interleukin-7; cellular response to nonylphenol; cellular response to transforming growth factor beta stimulus; cellular response to vitamin D; circadian rhythm; oxidation-reduction process; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of protein folding; protein folding; proteolysis; response to benzene; response to endoplasmic reticulum stress; response to ethanol; response to genistein; response to hyperoxia; response to hypoxia; response to ischemia; response to leptin; response to nutrient levels
Reference #:  P11598 (UniProtKB)
Alt. Names/Synonyms: 58 kDa glucose-regulated protein; 58 kDa microsomal protein; Disulfide isomerase ER-60; Endoplasmic reticulum resident protein 57; Endoplasmic reticulum resident protein 60; ER protein 57; ER protein 60; ER-60 protease; ER60; ERp57; ERp60; glucose regulated protein, 58 kDa; Grp58; HIP-70; oxidoreductase ERp57; p58; Pdia3; protein disulfide isomerase associated 3; protein disulfide isomerase family A, member 3; Protein disulfide-isomerase A3; Q-2
Gene Symbols: Pdia3
Molecular weight: 56,623 Da
Basal Isoelectric point: 5.88  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene