GRP58 Belongs to the protein disulfide isomerase family. Detected in the flagellum and head region of spermatozoa (at protein level). Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Chaperone; EC 5.3.4.1; Endoplasmic reticulum; Isomerase; Phospholipase; Protease
Chromosomal Location of Human Ortholog: 15q15.3
Cellular Component:  cell surface; endoplasmic reticulum; endoplasmic reticulum lumen; extracellular space; melanosome; MHC class I peptide loading complex; phagocytic vesicle; recycling endosome membrane
Molecular Function:  cysteine-type endopeptidase activity; disulfide oxidoreductase activity; identical protein binding; peptide disulfide oxidoreductase activity; phospholipase C activity; protein binding
Biological Process:  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of peptide antigen via MHC class I; cell redox homeostasis; cellular response to interleukin-7; oxidation-reduction process; positive regulation of extrinsic apoptotic signaling pathway; protein folding; protein folding in endoplasmic reticulum; proteolysis
Reference #:  P30101 (UniProtKB)
Alt. Names/Synonyms: 58 kDa glucose-regulated protein; 58 kDa microsomal protein; Disulfide isomerase ER-60; endoplasmic reticulum P58; Endoplasmic reticulum resident protein 57; Endoplasmic reticulum resident protein 60; ER protein 57; ER protein 60; ER60; ERP57; ERP60; ERp61; glucose regulated protein, 58kDa; GRP57; GRP58; HsT17083; p58; PDIA3; phospholipase C-alpha; PI-PLC; protein disulfide isomerase family A, member 3; protein disulfide isomerase-associated 3; Protein disulfide-isomerase A3
Gene Symbols: PDIA3
Molecular weight: 56,782 Da
Basal Isoelectric point: 5.98  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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GRP58

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB