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GRP58
Belongs to the protein disulfide isomerase family. Detected in the flagellum and head region of spermatozoa (at protein level). Note: This description may include information from UniProtKB.
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| Protein type: Apoptosis; Chaperone; EC 5.3.4.1; Endoplasmic reticulum; Isomerase; Phospholipase; Protease |
| Chromosomal Location of human Ortholog: 15q15.3 |
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Cellular Component:
cell surface; endoplasmic reticulum; endoplasmic reticulum lumen; extracellular space; melanosome; MHC class I peptide loading complex; phagocytic vesicle; recycling endosome membrane; Tapasin-ERp57 complex
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Molecular Function:
cysteine-type endopeptidase activity; disulfide oxidoreductase activity; identical protein binding; phospholipase C activity; protein binding; protein disulfide isomerase activity; protein-disulfide reductase activity
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Biological Process:
cellular response to interleukin-7; extrinsic apoptotic signaling pathway; peptide antigen assembly with MHC class I protein complex; platelet aggregation; positive regulation of extrinsic apoptotic signaling pathway; protein folding; protein folding in endoplasmic reticulum; response to endoplasmic reticulum stress
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Reference #:
P30101
(UniProtKB)
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Alt. Names/Synonyms: 58 kDa glucose-regulated protein; 58 kDa microsomal protein; Disulfide isomerase ER-60; endoplasmic reticulum P58; Endoplasmic reticulum resident protein 57; Endoplasmic reticulum resident protein 60; epididymis secretory protein Li 269; epididymis secretory sperm binding protein Li 93n; ER protein 57; ER protein 60; ER60; ERP57; ERP60; ERp61; glucose regulated protein, 58kDa; GRP57; GRP58; HEL-S-269; HEL-S-93n; HsT17083; p58; PDIA3; phospholipase C-alpha; PI-PLC; protein disulfide isomerase family A member 3; protein disulfide isomerase family A, member 3; protein disulfide isomerase-associated 3; Protein disulfide-isomerase A3
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Gene Symbols: PDIA3
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Molecular weight:
56,782 Da
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Basal Isoelectric point:
5.98
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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