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P2X7
Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. In the absence of its natural ligand, ATP, functions as a scavenger receptor in the recognition and engulfment of apoptotic cells. Belongs to the P2X receptor family. Widely expressed with highest levels in brain and immune tissues. 8 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. |
| Chromosomal Location of rat Ortholog: 12q16 |
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Cellular Component:
bleb; cell-cell junction; cytoplasm; external side of plasma membrane; membrane; mitochondrion; neuromuscular junction; neuronal cell body; nuclear envelope; plasma membrane; postsynapse; protein-containing complex; synapse; terminal bouton
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Molecular Function:
ATP binding; channel activity; copper ion binding; extracellularly ATP-gated monoatomic cation channel activity; identical protein binding; lipopolysaccharide binding; magnesium ion binding; monoatomic ion channel activity; protein binding; protein serine/threonine kinase activator activity; purinergic nucleotide receptor activity; scaffold protein binding; signaling receptor activity; signaling receptor binding; zinc ion binding
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Biological Process:
apoptotic signaling pathway; ATP export; bleb assembly; calcium ion transmembrane transport; calcium ion transport; cell morphogenesis; cell surface receptor signaling pathway; cell volume homeostasis; cellular response to dsRNA; cellular response to extracellular stimulus; cellular response to organic cyclic compound; ceramide biosynthetic process; collagen metabolic process; defense response to Gram-positive bacterium; establishment of localization in cell; excitatory postsynaptic potential; extrinsic apoptotic signaling pathway; gamma-aminobutyric acid secretion; gene expression; glutamate secretion; homeostasis of number of cells within a tissue; inflammatory response; lymphocyte apoptotic process; MAPK cascade; membrane depolarization; membrane protein ectodomain proteolysis; mitochondrial depolarization; mitochondrion organization; monoatomic cation transmembrane transport; monoatomic cation transport; monoatomic ion transmembrane transport; NAD transport; negative regulation of bone resorption; negative regulation of cell volume; negative regulation of MAPK cascade; neuronal action potential; phagolysosome assembly; phospholipid transfer to membrane; phospholipid translocation; plasma membrane organization; plasma membrane phospholipid scrambling; pore complex assembly; positive regulation of apoptotic process; positive regulation of bleb assembly; positive regulation of bone mineralization; positive regulation of calcium ion transport into cytosol; positive regulation of catalytic activity; positive regulation of cytoskeleton organization; positive regulation of gamma-aminobutyric acid secretion; positive regulation of gene expression; positive regulation of glutamate secretion; positive regulation of glycolytic process; positive regulation of interleukin-1 alpha production; positive regulation of interleukin-1 beta production; positive regulation of interleukin-6 production; positive regulation of lymphocyte apoptotic process; positive regulation of macrophage cytokine production; positive regulation of MAP kinase activity; positive regulation of MAPK cascade; positive regulation of mitochondrial depolarization; positive regulation of monoatomic ion transmembrane transport; positive regulation of ossification; positive regulation of prostaglandin secretion; positive regulation of protein phosphorylation; positive regulation of protein secretion; positive regulation of T cell apoptotic process; positive regulation of T cell mediated cytotoxicity; programmed cell death; prostaglandin secretion; protein catabolic process; protein phosphorylation; protein processing; protein secretion; purinergic nucleotide receptor signaling pathway; reactive oxygen species metabolic process; regulation of presynaptic dense core granule exocytosis; regulation of sodium ion transport; release of sequestered calcium ion into cytosol; response to ATP; response to bacterium; response to calcium ion; response to electrical stimulus; response to fluid shear stress; response to lipopolysaccharide; response to mechanical stimulus; response to organic cyclic compound; response to organic substance; response to xenobiotic stimulus; response to zinc ion; sensory perception of pain; skeletal system morphogenesis; synaptic vesicle exocytosis; T cell apoptotic process; T cell homeostasis; T cell mediated cytotoxicity; T cell proliferation; vesicle budding from membrane
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Reference #:
Q64663
(UniProtKB)
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Alt. Names/Synonyms: P2rx7; P2X purinoceptor 7; P2X7; P2X7 purinoceptor; P2Z receptor; purinergic receptor P2X, ligand-gated ion channel, 7; purinergic receptor P2X7
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Gene Symbols: P2rx7
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Molecular weight:
68,392 Da
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Basal Isoelectric point:
8.3
Predict pI for various phosphorylation states
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