P2X7 Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. In the absence of its natural ligand, ATP, functions as a scavenger receptor in the recognition and engulfment of apoptotic cells. Belongs to the P2X receptor family. Widely expressed with highest levels in brain and immune tissues. 8 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.
Chromosomal Location of human Ortholog: 12q24.31
Cellular Component:  bleb; cell-cell junction; cytoplasm; external side of plasma membrane; integral component of plasma membrane; membrane; neuromuscular junction; neuronal cell body; plasma membrane; postsynapse; presynapse
Molecular Function:  ATP binding; extracellularly ATP-gated cation channel activity; lipopolysaccharide binding; protein binding; protein homodimerization activity; purinergic nucleotide receptor activity; signaling receptor binding
Biological Process:  activation of MAPK activity; apoptotic signaling pathway; bleb assembly; blood coagulation; calcium ion transmembrane transport; calcium-mediated signaling using extracellular calcium source; cell morphogenesis; cell surface receptor signaling pathway; cell surface receptor signaling pathway involved in cell-cell signaling; cellular response to ATP; cellular response to dsRNA; ceramide biosynthetic process; collagen metabolic process; defense response to Gram-positive bacterium; excitatory postsynaptic potential; extrinsic apoptotic signaling pathway; homeostasis of number of cells within a tissue; inflammatory response; membrane depolarization; membrane protein ectodomain proteolysis; mitochondrion organization; NAD transport; negative regulation of bone resorption; negative regulation of cell volume; negative regulation of MAPK cascade; phagolysosome assembly; phospholipid scrambling; phospholipid transfer to membrane; pore complex assembly; positive regulation of bleb assembly; positive regulation of bone mineralization; positive regulation of calcium ion transport into cytosol; positive regulation of cytolysis; positive regulation of cytoskeleton organization; positive regulation of gamma-aminobutyric acid secretion; positive regulation of gene expression; positive regulation of glutamate secretion; positive regulation of glycolytic process; positive regulation of interleukin-1 alpha secretion; positive regulation of interleukin-1 beta secretion; positive regulation of interleukin-6 production; positive regulation of ion transmembrane transport; positive regulation of lymphocyte apoptotic process; positive regulation of mitochondrial depolarization; positive regulation of prostaglandin secretion; positive regulation of T cell mediated cytotoxicity; protein catabolic process; protein complex oligomerization; protein phosphorylation; protein processing; purinergic nucleotide receptor signaling pathway; reactive oxygen species metabolic process; regulation of killing of cells of other organism; regulation of sodium ion transport; release of sequestered calcium ion into cytosol; response to ATP; response to calcium ion; response to electrical stimulus; response to fluid shear stress; response to ischemia; response to lipopolysaccharide; response to mechanical stimulus; response to zinc ion; sensory perception of pain; skeletal system morphogenesis; synaptic vesicle exocytosis; T cell homeostasis; T cell proliferation; vesicle budding from membrane
Disease: Leukemia, Chronic Lymphocytic
Reference #:  Q99572 (UniProtKB)
Alt. Names/Synonyms: ATP receptor; MGC20089; P2RX7; P2X purinoceptor 7; P2X7; P2X7 receptor; P2Z receptor; Purinergic receptor; purinergic receptor P2X 7; purinergic receptor P2X, ligand gated ion channel, 7; purinergic receptor P2X, ligand-gated ion channel, 7; purinergic receptor P2X7 variant A; purnergic receptor P2X 7
Gene Symbols: P2RX7
Molecular weight: 68,585 Da
Basal Isoelectric point: 8.57  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein