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ABCA1
Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP. Thereby, participates to phospholipids transfer to apoliproteins to form nascent high density lipoproteins/HDLs. Transports preferentially phosphatidylcholine over phosphatidylserine. May involved indirectly in the efflux of intracellular cholesterol and its transfer to apoliproteins to form nascent high density lipoproteins/HDLs. Belongs to the ABC transporter superfamily. ABCA family. Widely expressed, but most abundant in macrophages. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family; Vesicle |
| Chromosomal Location of human Ortholog: 9q31.1 |
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Cellular Component:
basolateral plasma membrane; endocytic vesicle; endoplasmic reticulum membrane; endosome; external side of plasma membrane; Golgi apparatus; intracellular membrane-bounded organelle; intracellular vesicle; membrane raft; perinuclear region of cytoplasm; phagocytic vesicle; plasma membrane
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Molecular Function:
ABC-type transporter activity; apolipoprotein A-I binding; apolipoprotein A-I receptor activity; apolipoprotein binding; ATP binding; ATP hydrolysis activity; ATPase binding; ATPase-coupled transmembrane transporter activity; cholesterol binding; cholesterol transfer activity; floppase activity; high-density lipoprotein particle binding; phosphatidylcholine binding; phosphatidylcholine floppase activity; phosphatidylserine floppase activity; phospholipid transporter activity; protein binding; protein transmembrane transporter activity; signaling receptor binding; small GTPase binding; sphingolipid floppase activity; syntaxin binding
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Biological Process:
adenylate cyclase-activating G protein-coupled receptor signaling pathway; apolipoprotein A-I-mediated signaling pathway; cellular response to cholesterol; cellular response to cytokine stimulus; cellular response to lipopolysaccharide; cellular response to low-density lipoprotein particle stimulus; cellular response to retinoic acid; cellular response to xenobiotic stimulus; cholesterol efflux; cholesterol homeostasis; cholesterol metabolic process; endosomal transport; export across plasma membrane; G protein-coupled receptor signaling pathway; high-density lipoprotein particle assembly; intermembrane lipid transfer; intracellular cholesterol transport; lysosome organization; negative regulation of cholesterol storage; negative regulation of macrophage derived foam cell differentiation; peptide secretion; phagocytosis, engulfment; phospholipid efflux; phospholipid homeostasis; phospholipid translocation; platelet dense granule organization; positive regulation of cholesterol efflux; positive regulation of high-density lipoprotein particle assembly; protein lipidation; protein secretion; protein transmembrane transport; regulation of Cdc42 protein signal transduction; regulation of high-density lipoprotein particle assembly; response to laminar fluid shear stress; response to nutrient; reverse cholesterol transport; signal release; sphingolipid translocation
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Disease: Hypoalphalipoproteinemia, Primary; Tangier Disease
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Reference #:
O95477
(UniProtKB)
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Alt. Names/Synonyms: ABC-1; ABC1; ABCA1; ATP binding cassette subfamily A member 1; ATP-binding cassette 1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; ATP-binding cassette transporter A1; ATP-binding cassette, sub-family A (ABC1), member 1; CERP; Cholesterol efflux regulatory protein; FLJ14958; HDLCQTL13; HDLDT1; HPALP1; membrane-bound; MGC164864; MGC165011; Phospholipid-transporting ATPase ABCA1; TGD
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Gene Symbols: ABCA1
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Molecular weight:
254,302 Da
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Basal Isoelectric point:
6.43
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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