hnRNP I a ubiquitously expressed heterogeneous nuclear ribonucleoprotein (hnRNP). hnRNPs are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. Binds to the polypyrimidine tract of introns. May promote the binding of U2 snRNP to pre-mRNA. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: RNA splicing; RNA-binding
Chromosomal Location of Human Ortholog: 10 C1|10 39.72 cM
Cellular Component:  cytoplasm; neuron projection terminus; nucleus
Molecular Function:  mRNA binding; nucleic acid binding; pre-mRNA binding; protein binding; regulatory region RNA binding; RNA binding; sequence-specific DNA binding; single-stranded DNA binding; single-stranded DNA endodeoxyribonuclease activity
Biological Process:  3'-UTR-mediated mRNA stabilization; IRES-dependent viral translational initiation; mRNA processing; negative regulation of mRNA splicing, via spliceosome; negative regulation of muscle cell differentiation; negative regulation of neuron differentiation; negative regulation of RNA splicing; nuclear-transcribed mRNA catabolic process; positive regulation of calcineurin-NFAT signaling cascade; positive regulation of insulin secretion; positive regulation of neuron projection development; positive regulation of protein dephosphorylation; positive regulation of secretory granule organization; positive regulation of transcription by RNA polymerase II; positive regulation of translation; regulation of alternative mRNA splicing, via spliceosome; RNA splicing
Reference #:  P17225 (UniProtKB)
Alt. Names/Synonyms: AA407203; AL033359; Heterogeneous nuclear ribonucleoprotein I; hnRNP I; HNRPI; polypyrimidine tract binding protein 1; Polypyrimidine tract-binding protein 1; pPTB; PTB; PTB-1; PTB2; PTB3; PTB4; Ptbp1
Gene Symbols: Ptbp1
Molecular weight: 56,478 Da
Basal Isoelectric point: 8.47  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene