hnRNP I Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10. In case of infection by picornaviruses, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA splicing; RNA-binding
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component:  nucleolus; nucleoplasm
Molecular Function:  poly-pyrimidine tract binding; pre-mRNA binding; protein binding
Biological Process:  fibroblast growth factor receptor signaling pathway; IRES-dependent viral translational initiation; mRNA processing; mRNA splicing, via spliceosome; negative regulation of mRNA splicing, via spliceosome; negative regulation of muscle cell differentiation; negative regulation of RNA splicing; positive regulation of calcineurin-NFAT signaling cascade; positive regulation of protein dephosphorylation; regulation of alternative mRNA splicing, via spliceosome; RNA metabolic process; RNA splicing
Reference #:  P26599 (UniProtKB)
Alt. Names/Synonyms: 57 kDa RNA-binding protein PPTB-1; Heterogeneous nuclear ribonucleoprotein I; heterogeneous nuclear ribonucleoprotein polypeptide I; hnRNP I; HNRNP-I; HNRNPI; HNRPI; MGC10830; MGC8461; polypyrimidine tract binding protein (heterogeneous nuclear ribonucleoprotein I); polypyrimidine tract binding protein 1; Polypyrimidine tract-binding protein 1; pPTB; PTB; PTB-1; PTB-T; PTB2; PTB3; PTB4; PTBP1
Gene Symbols: PTBP1
Molecular weight: 57,221 Da
Basal Isoelectric point: 9.22  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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