AIP1 Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. Belongs to the MAGUK family. Specifically expressed in brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of rat Ortholog: 4q11
Cellular Component:  bicellular tight junction; cell-cell junction; centriole; ciliary base; cytoplasm; dendrite; extrinsic component of postsynaptic membrane; GABA-ergic synapse; glutamatergic synapse; late endosome; membrane; nucleus; perinuclear region of cytoplasm; photoreceptor inner segment; photoreceptor outer segment; plasma membrane; postsynaptic density; protein-containing complex; slit diaphragm; synapse
Molecular Function:  activin receptor binding; beta-1 adrenergic receptor binding; kinesin binding; phosphatase binding; protein binding; protein-containing complex binding; signaling receptor complex adaptor activity; SMAD binding; structural constituent of postsynaptic density; structural constituent of postsynaptic specialization; type II activin receptor binding
Biological Process:  cellular response to nerve growth factor stimulus; clathrin-dependent endocytosis; glomerular filtration; maintenance of postsynaptic density structure; negative regulation of activin receptor signaling pathway; negative regulation of cell migration; negative regulation of cell population proliferation; negative regulation of protein kinase B signaling; nerve growth factor signaling pathway; neuroligin clustering involved in postsynaptic membrane assembly; podocyte development; positive regulation of neuron projection development; positive regulation of phosphoprotein phosphatase activity; positive regulation of receptor internalization; positive regulation of synaptic vesicle clustering; receptor clustering; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane; regulation of synaptic membrane adhesion; signal transduction; SMAD protein signal transduction
Reference #:  O88382 (UniProtKB)
Alt. Names/Synonyms: activin receptor interacting protein 1; Acvrinp1; Acvrip1; AIP-1; Aip1; Atrophin-1-interacting protein 1; MAGI-2; Magi2; membrane associated guanylate kinase, WW and PDZ domain containing 2; Membrane-associated guanylate kinase inverted 2; Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2; S-SCAM; Sscam; Synaptic-scaffolding molecule
Gene Symbols: Magi2
Molecular weight: 141,072 Da
Basal Isoelectric point: 5.85  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene