AIP1 a scaffold molecule at synaptic junctions that apparently couples neurotransmitter receptors and cell adhesion proteins. Contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. Contains two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family. This protein is brain specific, where it appears to be widely expressed in both neurons and glia. Enhances the ability of PTEN to suppress AKT1 activation. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 4q11
Cellular Component:  bicellular tight junction; cell-cell junction; cytoplasm; dendrite; extrinsic component of postsynaptic membrane; GABA-ergic synapse; glutamatergic synapse; late endosome; nucleus; perinuclear region of cytoplasm; plasma membrane; postsynaptic density; protein-containing complex; slit diaphragm; synapse
Molecular Function:  activin receptor binding; beta-1 adrenergic receptor binding; kinesin binding; phosphatase binding; protein binding; protein-containing complex binding; receptor signaling complex scaffold activity; SMAD binding; structural constituent of postsynaptic density; structural constituent of postsynaptic specialization; type II activin receptor binding
Biological Process:  cellular response to nerve growth factor stimulus; glomerular filtration; glomerular visceral epithelial cell development; maintenance of postsynaptic density structure; mitotic cell cycle arrest; negative regulation of activin receptor signaling pathway; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of protein kinase B signaling; nerve growth factor signaling pathway; neuroligin clustering involved in postsynaptic membrane assembly; positive regulation of neuron projection development; positive regulation of phosphoprotein phosphatase activity; positive regulation of receptor internalization; positive regulation of signal transduction; positive regulation of synaptic vesicle clustering; protein heterooligomerization; receptor clustering; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane; regulation of synaptic membrane adhesion; signal transduction; SMAD protein signal transduction
Reference #:  O88382 (UniProtKB)
Alt. Names/Synonyms: activin receptor interacting protein 1; Acvrinp1; Acvrip1; AIP-1; Aip1; Atrophin-1-interacting protein 1; MAGI-2; Magi2; membrane associated guanylate kinase, WW and PDZ domain containing 2; Membrane-associated guanylate kinase inverted 2; Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2; S-SCAM; Sscam; Synaptic-scaffolding molecule
Gene Symbols: Magi2
Molecular weight: 141,072 Da
Basal Isoelectric point: 5.85  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene