AIP1
Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. Belongs to the MAGUK family. Specifically expressed in brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Adaptor/scaffold |
Chromosomal Location of human Ortholog: 7q21.11 |
Cellular Component:
bicellular tight junction; cell-cell junction; centriole; ciliary base; cytoplasm; dendrite; late endosome; nucleus; perinuclear region of cytoplasm; photoreceptor inner segment; photoreceptor outer segment; plasma membrane; postsynaptic density; protein-containing complex; slit diaphragm; synapse
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Molecular Function:
beta-1 adrenergic receptor binding; phosphatase binding; protein binding; signaling receptor complex adaptor activity; SMAD binding; type II activin receptor binding
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Biological Process:
cellular response to nerve growth factor stimulus; clathrin-dependent endocytosis; negative regulation of activin receptor signaling pathway; negative regulation of cell migration; negative regulation of cell population proliferation; negative regulation of protein kinase B signaling; nerve growth factor signaling pathway; nervous system development; planar cell polarity pathway involved in axis elongation; podocyte development; positive regulation of neuron projection development; positive regulation of phosphoprotein phosphatase activity; positive regulation of receptor internalization; receptor clustering; signal transduction; SMAD protein signal transduction
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Disease: Nephrotic Syndrome 15
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Reference #:
Q86UL8
(UniProtKB)
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Alt. Names/Synonyms: activin receptor interacting protein 1; ACVRINP1; ACVRIP1; AIP-1; AIP1; ARIP1; atrophin 1 interacting protein 1; atrophin-1 interacting protein A; Atrophin-1-interacting protein 1; Atrophin-1-interacting protein A; KIAA0705; MAGI-2; MAGI2; membrane associated guanylate kinase, WW and PDZ domain containing 2; Membrane-associated guanylate kinase inverted 2; Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2; NPHS15; SSCAM
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Gene Symbols: MAGI2
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Molecular weight:
158,754 Da
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Basal Isoelectric point:
5.95
Predict pI for various phosphorylation states
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