AIP1 Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. Belongs to the MAGUK family. Specifically expressed in brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 7q21.11
Cellular Component:  bicellular tight junction; cytoplasm; dendrite; late endosome; nucleus; perinuclear region of cytoplasm; plasma membrane; postsynaptic density; protein-containing complex; slit diaphragm; synapse
Molecular Function:  beta-1 adrenergic receptor binding; phosphatase binding; protein binding; receptor signaling complex scaffold activity; SMAD binding; type II activin receptor binding
Biological Process:  cellular response to nerve growth factor stimulus; glomerular visceral epithelial cell development; mitotic cell cycle arrest; negative regulation of activin receptor signaling pathway; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of protein kinase B signaling; nerve growth factor signaling pathway; neuroligin clustering involved in postsynaptic membrane assembly; planar cell polarity pathway involved in axis elongation; positive regulation of neuron projection development; positive regulation of phosphoprotein phosphatase activity; positive regulation of receptor internalization; positive regulation of signal transduction; positive regulation of synaptic vesicle clustering; protein heterooligomerization; receptor clustering; SMAD protein signal transduction
Disease: Nephrotic Syndrome 15
Reference #:  Q86UL8 (UniProtKB)
Alt. Names/Synonyms: activin receptor interacting protein 1; ACVRINP1; ACVRIP1; AIP-1; AIP1; ARIP1; atrophin 1 interacting protein 1; atrophin-1 interacting protein A; Atrophin-1-interacting protein 1; Atrophin-1-interacting protein A; KIAA0705; MAGI-2; MAGI2; membrane associated guanylate kinase, WW and PDZ domain containing 2; Membrane-associated guanylate kinase inverted 2; Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2; SSCAM
Gene Symbols: MAGI2
Molecular weight: 158,754 Da
Basal Isoelectric point: 5.95  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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