FAF1 Ubiquitin-binding protein. Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation. Potentiates but cannot initiate FAS-induced apoptosis. Most abundant in testis, slightly less abundant in skeletal muscle and heart, followed by prostate, thymus, ovary, small intestine, and colon. Not detected in the peripheral blood leukocytes. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 4 C7|4 51.33 cM
Cellular Component:  cytoplasm; cytosol; nuclear envelope; nucleus; perinuclear region of cytoplasm; VCP-NPL4-UFD1 AAA ATPase complex
Molecular Function:  heat shock protein binding; NF-kappaB binding; protein binding; protein domain specific binding; protein kinase binding; ubiquitin binding; ubiquitin protein ligase binding
Biological Process:  apoptotic process; cell death; cytoplasmic sequestering of NF-kappaB; positive regulation of cell death; positive regulation of cellular protein catabolic process; positive regulation of DNA replication; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; positive regulation of protein complex assembly; regulation of cell adhesion; regulation of protein catabolic process
Reference #:  P54731 (UniProtKB)
Alt. Names/Synonyms: AA408698; Dffr; Dffrx; Faf1; Fam; FAS-associated factor 1; OTTMUSP00000008830
Gene Symbols: Faf1
Molecular weight: 73,863 Da
Basal Isoelectric point: 4.78  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA