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FAF1
Ubiquitin-binding protein. Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation. Potentiates but cannot initiate FAS-induced apoptosis. Most abundant in testis, slightly less abundant in skeletal muscle and heart, followed by prostate, thymus, ovary, small intestine, and colon. Not detected in the peripheral blood leukocytes. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Apoptosis; Nuclear receptor co-regulator |
| Chromosomal Location of human Ortholog: 1p32.3 |
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Cellular Component:
CD95 death-inducing signaling complex; cytosol; endoplasmic reticulum; nuclear envelope; nucleoplasm; nucleus; ooplasm; perinuclear region of cytoplasm; VCP-NPL4-UFD1 AAA ATPase complex
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Molecular Function:
heat shock protein binding; NF-kappaB binding; protein binding; protein domain specific binding; protein kinase binding; protein kinase regulator activity; ubiquitin binding; ubiquitin protein ligase binding
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Biological Process:
apoptotic process; cytoplasmic sequestering of NF-kappaB; positive regulation of apoptotic process; positive regulation of DNA replication; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; positive regulation of protein catabolic process; positive regulation of protein-containing complex assembly; proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of cell adhesion; regulation of protein catabolic process; ubiquitin-dependent ERAD pathway
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Reference #:
Q9UNN5
(UniProtKB)
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Alt. Names/Synonyms: CGI-03; FAF1; Fas (TNFRSF6) associated factor 1; Fas associated factor 1; FAS-associated factor 1; FLJ37524; hFAF1; HFAF1s; TNFRSF6-associated factor 1; UBX domain protein 3A; UBX domain-containing protein 12; UBX domain-containing protein 3A; UBXD12; UBXN3A
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Gene Symbols: FAF1
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Molecular weight:
73,954 Da
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Basal Isoelectric point:
4.81
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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