FAF1 Ubiquitin-binding protein. Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation. Potentiates but cannot initiate FAS-induced apoptosis. Most abundant in testis, slightly less abundant in skeletal muscle and heart, followed by prostate, thymus, ovary, small intestine, and colon. Not detected in the peripheral blood leukocytes. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 1p32.3
Cellular Component:  CD95 death-inducing signaling complex; cytosol; nuclear envelope; nucleus; perinuclear region of cytoplasm; VCP-NPL4-UFD1 AAA ATPase complex
Molecular Function:  heat shock protein binding; NF-kappaB binding; protein binding; protein domain specific binding; protein kinase binding; protein kinase regulator activity; ubiquitin binding; ubiquitin protein ligase binding
Biological Process:  apoptotic process; cell death; cytoplasmic sequestering of NF-kappaB; positive regulation of apoptotic process; positive regulation of cell death; positive regulation of cellular protein catabolic process; positive regulation of DNA replication; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; positive regulation of protein complex assembly; proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of cell adhesion; regulation of protein catabolic process; regulation of protein kinase activity
Reference #:  Q9UNN5 (UniProtKB)
Alt. Names/Synonyms: CGI-03; FAF1; Fas (TNFRSF6) associated factor 1; Fas associated factor 1; FAS-associated factor 1; FLJ37524; hFAF1; HFAF1s; TNFRSF6-associated factor 1; UBX domain protein 3A; UBX domain-containing protein 12; UBX domain-containing protein 3A; UBXD12; UBXN3A
Gene Symbols: FAF1
Molecular weight: 73,954 Da
Basal Isoelectric point: 4.81  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA