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CD28
Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells. Expressed in T-cells and plasma cells, but not in less mature B-cells. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell surface; Membrane protein, integral |
| Chromosomal Location of human Ortholog: 2q33.2 |
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Cellular Component:
cell surface; cytosol; external side of plasma membrane; immunological synapse; plasma membrane; protein complex involved in cell adhesion
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Molecular Function:
coreceptor activity; identical protein binding; protease binding; protein binding; protein kinase binding
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Biological Process:
apoptotic signaling pathway; CD4-positive, alpha-beta T cell proliferation; cell surface receptor signaling pathway; humoral immune response; negative regulation of apoptotic process; negative regulation of gene expression; negative thymic T cell selection; phosphatidylinositol 3-kinase signaling; positive regulation of CD4-positive, alpha-beta T cell proliferation; positive regulation of cytokine production; positive regulation of gene expression; positive regulation of inflammatory response to antigenic stimulus; positive regulation of interleukin-10 production; positive regulation of interleukin-2 production; positive regulation of interleukin-4 production; positive regulation of isotype switching to IgG isotypes; positive regulation of mitotic nuclear division; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of protein kinase B signaling; positive regulation of T cell proliferation; positive regulation of transcription by RNA polymerase II; positive regulation of translation; positive regulation of viral genome replication; protein kinase B signaling; regulation of regulatory T cell differentiation; regulatory T cell differentiation; T cell activation; T cell costimulation; T cell receptor signaling pathway; transcription by RNA polymerase II
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Disease: Immunodeficiency 123 With Hpv-related Verrucosis
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Reference #:
P10747
(UniProtKB)
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Alt. Names/Synonyms: CD28; CD28 antigen; CD28 molecule; MGC138290; T-cell-specific surface glycoprotein CD28; TP44
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Gene Symbols: CD28
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Molecular weight:
25,066 Da
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Basal Isoelectric point:
9.46
Predict pI for various phosphorylation states
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CST Pathways:
T Cell Receptor Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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