PEA-15 Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm. Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface. Ubiquitously expressed. Most abundant in tissues such as heart, brain, muscle and adipose tissue which utilize glucose as an energy source. Lower expression in glucose-producing tissues. Higher levels of expression are found in tissues from individuals with type 2 diabetes than in controls. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Motility/polarity/chemotaxis
Chromosomal Location of human Ortholog: 1q23.2
Cellular Component:  cytosol; microtubule associated complex; nucleus
Molecular Function:  protein binding
Biological Process:  activation of MAPK activity; apoptotic process; carbohydrate transport; DNA damage checkpoint; MAPK cascade; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; negative regulation of glucose import; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; response to morphine
Reference #:  Q15121 (UniProtKB)
Alt. Names/Synonyms: 15 kDa phosphoprotein enriched in astrocytes; Astrocytic phosphoprotein PEA-15; HMAT1; homolog of mouse MAT-1 oncogene; HUMMAT1H; mammary transforming gene 1, mouse, homolog of; MAT1; MAT1H; PEA-15; PEA15; PED; PED-PEA15; PED/PEA15; phosphoprotein enriched in astrocytes 15; Phosphoprotein enriched in astrocytes, 15kD; Phosphoprotein enriched in diabetes; proliferation and apoptosis adaptor 15; proliferation and apoptosis adaptor protein 15
Gene Symbols: PEA15
Molecular weight: 15,040 Da
Basal Isoelectric point: 4.93  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene