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DYRK1A
Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6. Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: CMGC group; DYRK family; DYRK1 subfamily; EC 2.7.12.2; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) |
| Chromosomal Location of rat Ortholog: 11q11 |
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Cellular Component:
actin filament; axon; cytoplasm; cytoskeleton; dendrite; microtubule; neurofilament; nuclear speck; nucleolus; nucleus; ribonucleoprotein complex
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Molecular Function:
actin binding; ATP binding; cytoskeletal protein binding; histone H3T45 kinase activity; identical protein binding; non-membrane spanning protein tyrosine kinase activity; protein kinase activity; protein self-association; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity; RNA polymerase II CTD heptapeptide repeat kinase activity; tau protein binding; transcription coactivator activity; tubulin binding
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Biological Process:
amyloid-beta formation; chromatin remodeling; circadian rhythm; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of DNA methylation-dependent heterochromatin formation; negative regulation of microtubule polymerization; negative regulation of mRNA splicing, via spliceosome; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; peptidyl-tyrosine autophosphorylation; peptidyl-tyrosine phosphorylation; positive regulation of DNA-templated transcription; positive regulation of protein deacetylation; positive regulation of RNA splicing; protein autophosphorylation; protein phosphorylation; regulation of alternative mRNA splicing, via spliceosome; regulation of transcription by RNA polymerase II
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Reference #:
Q63470
(UniProtKB)
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Alt. Names/Synonyms: Dual specificity tyrosine-phosphorylation-regulated kinase 1A; Dual specificity YAK1-related kinase; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A; DYR1A; Dyrk; Dyrk1a; MNBH; Protein kinase minibrain homolog; PSK47; RP86
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Gene Symbols: Dyrk1a
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Molecular weight:
85,541 Da
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Basal Isoelectric point:
8.9
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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