14-3-3 sigma Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53. p53-regulated inhibitor of G2/M progression. Belongs to the 14-3-3 family. Present mainly in tissues enriched in stratified squamous keratinizing epithelium. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 1p36.11
Cellular Component:  cytosol; extracellular space; mitochondrion; nucleus
Molecular Function:  identical protein binding; phosphoprotein binding; protein binding; protein domain specific binding; protein kinase binding; protein kinase C inhibitor activity
Biological Process:  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; establishment of skin barrier; intrinsic apoptotic signaling pathway in response to DNA damage; keratinization; keratinocyte development; membrane organization; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of keratinocyte proliferation; negative regulation of protein kinase activity; negative regulation of protein serine/threonine kinase activity; positive regulation of cell growth; positive regulation of epidermal cell differentiation; positive regulation of protein export from nucleus; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of epidermal cell division; release of cytochrome c from mitochondria; signal transduction
Reference #:  P31947 (UniProtKB)
Alt. Names/Synonyms: 14-3-3 protein sigma; 14-3-3 sigma; 1433S; Epithelial cell marker protein 1; HME1; SFN; stratifin; YWHAS
Gene Symbols: SFN
Molecular weight: 27,774 Da
Basal Isoelectric point: 4.68  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  G2/M DNA Damage Checkpoint  |  Growth And Differentiation Control by MAPKs  |  Hippo Signaling  |  Mitochondrial Control of Apoptosis  |  PI3K/Akt Signaling  |  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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14-3-3 sigma

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene