CDC42 iso1 Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. Facilitates filopodia formation upon DOCK11-activation. Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling. Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups. Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily. 1 alternatively spliced human isoform has been reported. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 4 D3|4 69.83 cM
Cellular Component:  apical part of cell; cell cortex; cell periphery; cell projection; cell-cell junction; cytoplasm; cytoskeleton; cytosol; dendritic spine; Golgi membrane; leading edge membrane; membrane; neuron projection; phagocytic vesicle; plasma membrane; Schaffer collateral - CA1 synapse; secretory granule; storage vacuole
Molecular Function:  GTP binding; GTP-dependent protein binding; GTPase activity; mitogen-activated protein kinase kinase kinase binding; nucleotide binding; protein binding; protein kinase binding; Rho GDP-dissociation inhibitor binding
Biological Process:  actin cytoskeleton organization; actin filament branching; actin filament organization; adherens junction organization; cardiac conduction system development; Cdc42 protein signal transduction; cell differentiation; cell projection assembly; cell-cell adhesion; cellular protein localization; cellular response to interferon-gamma; dendritic cell migration; dendritic spine morphogenesis; endocytosis; endosomal transport; establishment of Golgi localization; establishment or maintenance of apical/basal cell polarity; establishment or maintenance of cell polarity; filopodium assembly; Golgi organization; heart contraction; modification of synaptic structure; nervous system development; neuron fate determination; nuclear migration; nucleus localization; organelle transport along microtubule; positive regulation of catalytic activity; positive regulation of DNA replication; positive regulation of epithelial cell proliferation involved in lung morphogenesis; positive regulation of filopodium assembly; positive regulation of intracellular protein transport; positive regulation of JNK cascade; positive regulation of MAPK cascade; positive regulation of neuron apoptotic process; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of synapse structural plasticity; regulation of actin cytoskeleton organization; regulation of cell shape; regulation of mitotic nuclear division; regulation of modification of postsynaptic structure; regulation of protein heterodimerization activity; Rho protein signal transduction; small GTPase mediated signal transduction; sprouting angiogenesis
Reference #:  P60766-1 (UniProtKB)
Alt. Names/Synonyms: AI747189; AU018915; Cdc42; Cell division control protein 42 homolog; cell division cycle 42 homolog (S. cerevisiae); G25K GTP-binding protein; OTTMUSP00000010388; RP23-246F18.2
Gene Symbols: Cdc42
Molecular weight: 21,311 Da
Basal Isoelectric point: 5.76  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Microtubule Dynamics  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-ß Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CDC42 iso1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene