CDC42 iso1 a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. Causes the formation of thin, actin-rich surface projections called filopodia. The oncoprotein Dbl specifically catalyzes the dissociation of GDP from this protein. Regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Interacts with DOCK9 which activates it by exchanging GDP for GTP. Interacts with PARD6A, PARD6B and PARD6G in a GTP-dependent manner. Part of a complex with PARD3, PARD6A or PARD6B and PRKCI or PRKCZ. Interacts with CDC42EP4.Alternative splicing of this gene results in at least two transcript variants. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 4 D3|4 69.83 cM
Cellular Component:  apical part of cell; cell cortex; cell periphery; cell projection; cell-cell junction; cytoplasm; cytoskeleton; cytosol; dendritic spine; Golgi membrane; leading edge membrane; membrane; neuron projection; phagocytic vesicle; plasma membrane; Schaffer collateral - CA1 synapse; secretory granule; storage vacuole
Molecular Function:  GTP binding; GTP-dependent protein binding; GTPase activity; mitogen-activated protein kinase kinase kinase binding; nucleotide binding; protein binding; protein kinase binding; Rho GDP-dissociation inhibitor binding
Biological Process:  actin cytoskeleton organization; actin filament branching; actin filament organization; adherens junction organization; cardiac conduction system development; Cdc42 protein signal transduction; cell differentiation; cell projection assembly; cell-cell adhesion; cellular protein localization; cellular response to interferon-gamma; dendritic cell migration; dendritic spine morphogenesis; endocytosis; endosomal transport; establishment of Golgi localization; establishment or maintenance of apical/basal cell polarity; establishment or maintenance of cell polarity; filopodium assembly; Golgi organization; heart contraction; modification of synaptic structure; nervous system development; neuron fate determination; nuclear migration; nucleus localization; organelle transport along microtubule; positive regulation of catalytic activity; positive regulation of DNA replication; positive regulation of epithelial cell proliferation involved in lung morphogenesis; positive regulation of filopodium assembly; positive regulation of intracellular protein transport; positive regulation of JNK cascade; positive regulation of MAPK cascade; positive regulation of neuron apoptotic process; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of synapse structural plasticity; regulation of actin cytoskeleton organization; regulation of cell shape; regulation of mitotic nuclear division; regulation of modification of postsynaptic structure; regulation of protein heterodimerization activity; Rho protein signal transduction; small GTPase mediated signal transduction; sprouting angiogenesis
Reference #:  P60766-1 (UniProtKB)
Alt. Names/Synonyms: AI747189; AU018915; Cdc42; Cell division control protein 42 homolog; cell division cycle 42 homolog (S. cerevisiae); G25K GTP-binding protein; OTTMUSP00000010388; RP23-246F18.2
Gene Symbols: Cdc42
Molecular weight: 21,311 Da
Basal Isoelectric point: 5.76  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Microtubule Dynamics  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-ß Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CDC42 iso1

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene