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IP3R1
Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways. Belongs to the InsP3 receptor family. Widely expressed. 8 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass |
| Chromosomal Location of human Ortholog: 3p26.1 |
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Cellular Component:
calcineurin complex; endoplasmic reticulum; endoplasmic reticulum membrane; nuclear inner membrane; nucleolus; perinuclear region of cytoplasm; plasma membrane; platelet dense granule membrane; platelet dense tubular network; platelet dense tubular network membrane; postsynaptic density; sarcoplasmic reticulum; Schaffer collateral - CA1 synapse; secretory granule membrane; transport vesicle membrane
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Molecular Function:
calcium channel inhibitor activity; calcium ion binding; calcium ion transmembrane transporter activity; calcium-release channel activity; inositol 1,4,5 trisphosphate binding; inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels; inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; phosphatidylinositol binding; protein binding; protein domain specific binding
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Biological Process:
calcium ion transport; cell morphogenesis; endoplasmic reticulum calcium ion homeostasis; epithelial fluid transport; inositol phosphate-mediated signaling; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; ion channel modulating, G protein-coupled receptor signaling pathway; ligand-gated ion channel signaling pathway; negative regulation of calcium-mediated signaling; phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway; positive regulation of insulin secretion; post-embryonic development; regulation of autophagy; regulation of postsynaptic cytosolic calcium ion concentration; release of sequestered calcium ion into cytosol; response to hypoxia; signal transduction; voluntary musculoskeletal movement
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Disease: Aniridia, Cerebellar Ataxia, And Mental Retardation; Spinocerebellar Ataxia 15; Spinocerebellar Ataxia 29
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Reference #:
Q14643
(UniProtKB)
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Alt. Names/Synonyms: ACV; CLA4; DKFZp313E1334; DKFZp313N1434; inositol 1,4,5-triphosphate receptor, type 1; Inositol 1,4,5-trisphosphate receptor type 1; INSP3R1; IP3 receptor; IP3 receptor isoform 1; IP3R; IP3R 1; IP3R1; ITPR1; PPP1R94; protein phosphatase 1, regulatory subunit 94; SCA15; SCA16; SCA29; Type 1 inositol 1,4,5-trisphosphate receptor; Type 1 InsP3 receptor
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Gene Symbols: ITPR1
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Molecular weight:
313,929 Da
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Basal Isoelectric point:
5.71
Predict pI for various phosphorylation states
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CST Pathways:
B Cell Receptor Signaling
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Phospholipase Signaling
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T Cell Receptor Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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