IP3R1
Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways. Belongs to the InsP3 receptor family. Widely expressed. 8 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Molecular Function: calcium channel activity; calcium channel inhibitor activity; calcium ion binding; calcium-release channel activity; identical protein binding; inositol 1,4,5 trisphosphate binding; inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels; inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; monoatomic ion channel activity; phosphatidylinositol binding; protein binding; protein domain specific binding; protein phosphatase binding; protein-containing complex binding; transmembrane transporter binding
Biological Process: apoptotic process; calcium ion transmembrane transport; calcium ion transport; calcium-mediated signaling; cell morphogenesis; cellular response to cAMP; endoplasmic reticulum calcium ion homeostasis; epithelial fluid transport; inositol phosphate-mediated signaling; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; ion channel modulating, G protein-coupled receptor signaling pathway; ligand-gated ion channel signaling pathway; liver regeneration; monoatomic ion transport; negative regulation of apoptotic process; negative regulation of calcium-mediated signaling; phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway; phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of apoptotic process; positive regulation of calcium ion transport; positive regulation of cytosolic calcium ion concentration; positive regulation of hepatocyte proliferation; positive regulation of insulin secretion; positive regulation of neuron projection development; post-embryonic development; regulation of postsynaptic cytosolic calcium ion concentration; release of sequestered calcium ion into cytosol; response to hypoxia; transmembrane transport; voluntary musculoskeletal movement
