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MPL
Receptor for thrombopoietin that acts as a primary regulator of megakaryopoiesis and platelet production. May represent a regulatory molecule specific for TPO-R-dependent immune responses. Belongs to the type I cytokine receptor family. Type 1 subfamily. Expressed at a low level in a large number of cells of hematopoietic origin. Isoform 1 and isoform 2 are always found to be coexpressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Receptor, cytokine |
| Chromosomal Location of human Ortholog: 1p34.2 |
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Cellular Component:
cell surface; external side of plasma membrane; Golgi apparatus; neuronal cell body; nuclear membrane; plasma membrane
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Molecular Function:
protein binding; thrombopoietin receptor activity
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Biological Process:
basophil homeostasis; cellular response to hypoxia; eosinophil homeostasis; immunoglobulin mediated immune response; monocyte homeostasis; neutrophil homeostasis; positive regulation of lymphocyte proliferation; positive regulation of platelet formation; thrombopoietin-mediated signaling pathway
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Disease: Amegakaryocytic Thrombocytopenia, Congenital; Myelofibrosis; Thrombocythemia 2
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Reference #:
P40238
(UniProtKB)
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Alt. Names/Synonyms: C-MPL; CD110; MPL; MPL proto-oncogene, thrombopoietin receptor; MPLV; Myeloproliferative leukemia protein; myeloproliferative leukemia virus oncogene; Proto-oncogene c-Mpl; THCYT2; THPOR; Thrombopoietin receptor; TPO-R; TPOR
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Gene Symbols: MPL
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Molecular weight:
71,245 Da
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Basal Isoelectric point:
6.03
Predict pI for various phosphorylation states
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