MPL Receptor for thrombopoietin that acts as a primary regulator of megakaryopoiesis and platelet production. May represent a regulatory molecule specific for TPO-R-dependent immune responses. Belongs to the type I cytokine receptor family. Type 1 subfamily. Expressed at a low level in a large number of cells of hematopoietic origin. Isoform 1 and isoform 2 are always found to be coexpressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of human Ortholog: 1p34.2
Cellular Component:  cell surface; external side of plasma membrane; Golgi apparatus; neuronal cell body; nuclear membrane; plasma membrane
Molecular Function:  protein binding; thrombopoietin receptor activity
Biological Process:  basophil homeostasis; cellular response to hypoxia; eosinophil homeostasis; immunoglobulin mediated immune response; monocyte homeostasis; neutrophil homeostasis; positive regulation of lymphocyte proliferation; positive regulation of platelet formation; thrombopoietin-mediated signaling pathway
Disease: Amegakaryocytic Thrombocytopenia, Congenital; Myelofibrosis; Thrombocythemia 2
Reference #:  P40238 (UniProtKB)
Alt. Names/Synonyms: C-MPL; CD110; MPL; MPL proto-oncogene, thrombopoietin receptor; MPLV; Myeloproliferative leukemia protein; myeloproliferative leukemia virus oncogene; Proto-oncogene c-Mpl; THCYT2; THPOR; Thrombopoietin receptor; TPO-R; TPOR
Gene Symbols: MPL
Molecular weight: 71,245 Da
Basal Isoelectric point: 6.03  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein