CRF-R1 G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli. Belongs to the G-protein coupled receptor 2 family. Predominantly expressed in the cerebellum, pituitary, cerebral cortex and olfactory lobe. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 11 E1|11 67.77 cM
Cellular Component:  apical part of cell; dendrite; endosome; integral component of membrane; intrinsic component of plasma membrane; membrane; multivesicular body; neuronal cell body; plasma membrane; trans-Golgi network; vesicle
Molecular Function:  corticotrophin-releasing factor receptor activity; corticotropin-releasing hormone binding; corticotropin-releasing hormone receptor activity; G protein-coupled receptor activity; G-protein alpha-subunit binding; peptide binding; peptide hormone binding; protein binding; protein-containing complex binding; transmembrane signaling receptor activity
Biological Process:  adenylate cyclase-activating G protein-coupled receptor signaling pathway; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; adrenal gland development; behavioral response to cocaine; behavioral response to ethanol; behavioral response to pain; cell surface receptor signaling pathway; cellular response to corticotropin-releasing hormone stimulus; corticotropin secretion; epithelial cell differentiation; fear response; feeding behavior; general adaptation syndrome, behavioral process; locomotory exploration behavior; long-term synaptic potentiation; memory; negative regulation of epinephrine secretion; negative regulation of feeding behavior; negative regulation of neuron death; negative regulation of voltage-gated calcium channel activity; neuropeptide signaling pathway; phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of cAMP-mediated signaling; positive regulation of cytosolic calcium ion concentration; positive regulation of mast cell degranulation; regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway; regulation of corticosterone secretion; regulation of synaptic plasticity; response to electrical stimulus; response to hypoxia; signal transduction; visual learning
Reference #:  P35347 (UniProtKB)
Alt. Names/Synonyms: corticotropin releasing hormone receptor 1; Corticotropin-releasing factor receptor 1; Corticotropin-releasing hormone receptor 1; CRF 1 receptor; CRF-R-1; CRF-R1; CRF-R1alpha; CRFR-1; CRFR1; CRH-R-1; CRH-R1; Crhr; Crhr1; MGC124237; MGC124240; OTTMUSP00000003077
Gene Symbols: Crhr1
Molecular weight: 47,769 Da
Basal Isoelectric point: 9.65  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene