RAP1GAP GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. Significant expression seen in the brain, kidney and pancreas. Abundant in the cerebral cortex and expressed at much lower levels in the spinal cord. Not detected in the lymphoid tissues. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, Ras; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 1p36.12
Cellular Component:  cytosol; Golgi membrane; membrane
Molecular Function:  GTPase activator activity; GTPase activity; protein binding; protein homodimerization activity; Ras GTPase binding
Biological Process:  axon guidance; negative regulation of microvillus assembly; positive regulation of GTPase activity; regulation of GTPase activity; regulation of small GTPase mediated signal transduction; signal transduction
Reference #:  P47736 (UniProtKB)
Alt. Names/Synonyms: KIAA0474; RAP1 GTPase activating protein; Rap1 GTPase-activating protein 1; RAP1, GTPase activating protein 1; RAP1GA1; RAP1GAP; Rap1GAP1; RAP1GAPII; RAPGAP; RPGP1
Gene Symbols: RAP1GAP
Molecular weight: 73,361 Da
Basal Isoelectric point: 5.55  Predict pI for various phosphorylation states
Select Structure to View Below

RAP1GAP

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein