dematin Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Plays also a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation. Belongs to the villin/gelsolin family. Expressed in platelets (at protein level). Expressed in heart, brain, lung, skeletal muscle, and kidney. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motility/polarity/chemotaxis; Tumor suppressor
Chromosomal Location of human Ortholog: 8p21.3
Cellular Component:  actin cytoskeleton; actin filament; cell projection membrane; cortical cytoskeleton; cytoplasmic vesicle; cytosol; endomembrane system; perinuclear region of cytoplasm; plasma membrane; platelet dense tubular network membrane; postsynaptic density; spectrin-associated cytoskeleton
Molecular Function:  actin binding; actin filament binding; protein binding; protein self-association; signaling receptor binding; spectrin binding
Biological Process:  actin cytoskeleton organization; actin filament bundle assembly; actin filament capping; calcium-mediated signaling using intracellular calcium source; cellular response to calcium ion; cellular response to cAMP; cytoskeleton organization; erythrocyte development; lamellipodium assembly; negative regulation of cell-substrate adhesion; negative regulation of focal adhesion assembly; negative regulation of peptidyl-serine phosphorylation; negative regulation of peptidyl-threonine phosphorylation; negative regulation of peptidyl-tyrosine phosphorylation; negative regulation of protein targeting to membrane; negative regulation of substrate adhesion-dependent cell spreading; positive regulation of blood coagulation; positive regulation of fibroblast migration; positive regulation of wound healing; protein-containing complex assembly; regulation of actin cytoskeleton organization; regulation of cell shape; regulation of filopodium assembly; regulation of lamellipodium assembly
Reference #:  Q08495 (UniProtKB)
Alt. Names/Synonyms: DEMA; Dematin; dematin actin binding protein; Dematin actin-binding protein; DMT; DMTN; EPB49; Erythrocyte membrane protein band 4.9; erythrocyte membrane protein band 4.9 (dematin); FLJ78462; FLJ98848
Gene Symbols: DMTN
Molecular weight: 45,514 Da
Basal Isoelectric point: 8.94  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein