N-WASP Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex. Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization. Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression. Plays a role in dendrite spine morphogenesis. Decreasing levels of DNMBP (using antisense RNA) alters apical junction morphology in cultured enterocytes, junctions curve instead of being nearly linear. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 6|6 A3.1
Cellular Component:  actin cap; actin cortical patch; actin filament; cell leading edge; cytoplasm; cytoplasmic vesicle; cytoskeleton; glutamatergic synapse; Golgi membrane; lamellipodium; nucleus; postsynapse
Molecular Function:  actin binding; actin filament binding; cytoskeletal protein binding; identical protein binding; protein binding
Biological Process:  actin cortical patch assembly; actin cortical patch localization; actin cytoskeleton organization; actin filament organization; actin filament-based movement; actin nucleation; cell cycle; cell division; cellular protein-containing complex localization; dendritic spine morphogenesis; endocytosis; membrane invagination; plasma membrane tubulation; positive regulation of Arp2/3 complex-mediated actin nucleation; positive regulation of clathrin-dependent endocytosis; positive regulation of filopodium assembly; postsynaptic actin cytoskeleton organization; regulation of protein localization; response to bacterium; spindle localization; vesicle budding from membrane; vesicle organization; vesicle transport along actin filament
Reference #:  Q91YD9 (UniProtKB)
Alt. Names/Synonyms: 2900021I12Rik; 3110031I02Rik; N-WASP; Neural Wiskott-Aldrich syndrome protein; Wasl; WASP like actin nucleation promoting factor; Wiskott-Aldrich syndrome-like; Wiskott-Aldrich syndrome-like (human)
Gene Symbols: Wasl
Molecular weight: 54,274 Da
Basal Isoelectric point: 8.05  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene