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N-WASP
Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex. Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization. Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression. Plays a role in dendrite spine morphogenesis. Decreasing levels of DNMBP (using antisense RNA) alters apical junction morphology in cultured enterocytes, junctions curve instead of being nearly linear. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis |
| Chromosomal Location of mouse Ortholog: 6|6 A3.1 |
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Cellular Component:
actin cap; cell leading edge; cytoplasm; cytoplasmic vesicle; cytoskeleton; cytosol; glutamatergic synapse; Golgi membrane; lamellipodium; nucleus; postsynapse
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Molecular Function:
actin binding; cytoskeletal protein binding; identical protein binding; protein binding
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Biological Process:
actin cytoskeleton organization; actin filament organization; actin filament polymerization; actin nucleation; cell cycle; cell division; cell projection assembly; dendritic spine morphogenesis; membrane invagination; negative regulation of lymphocyte migration; negative regulation of membrane tubulation; plasma membrane tubulation; positive regulation of chemotaxis; positive regulation of clathrin-dependent endocytosis; positive regulation of filopodium assembly; positive regulation of transcription by RNA polymerase II; postsynapse organization; postsynaptic actin cytoskeleton organization; protein-containing complex localization; regulation of cell projection assembly; regulation of postsynapse organization; regulation of protein localization; response to bacterium; spindle localization; vesicle budding from membrane; vesicle organization; vesicle transport along actin filament
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Reference #:
Q91YD9
(UniProtKB)
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Alt. Names/Synonyms: 2900021I12Rik; 3110031I02Rik; Actin nucleation-promoting factor WASL; N-WASP; Neural Wiskott-Aldrich syndrome protein; Wasl; WASP like actin nucleation promoting factor; Wiskott-Aldrich syndrome-like; Wiskott-Aldrich syndrome-like (human)
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Gene Symbols: Wasl
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Molecular weight:
54,274 Da
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Basal Isoelectric point:
8.05
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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