N-WASP Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex. Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization. Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression. Plays a role in dendrite spine morphogenesis. Decreasing levels of DNMBP (using antisense RNA) alters apical junction morphology in cultured enterocytes, junctions curve instead of being nearly linear. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 7q31.32
Cellular Component:  actin cap; actin cytoskeleton; cytoplasmic vesicle; cytosol; endocytic vesicle membrane; lamellipodium; nucleus; plasma membrane
Molecular Function:  GTPase regulator activity; protein binding
Biological Process:  actin filament polymerization; actin polymerization or depolymerization; cell division; cellular protein-containing complex localization; dendritic spine morphogenesis; ephrin receptor signaling pathway; Fc-gamma receptor signaling pathway involved in phagocytosis; membrane organization; negative regulation of lymphocyte migration; negative regulation of membrane tubulation; positive regulation of Arp2/3 complex-mediated actin nucleation; positive regulation of clathrin-dependent endocytosis; positive regulation of filopodium assembly; positive regulation of transcription by RNA polymerase II; protein-containing complex assembly; regulation of nitric-oxide synthase activity; regulation of protein localization; response to bacterium; spindle localization; vesicle budding from membrane; vesicle organization; vesicle transport along actin filament
Reference #:  O00401 (UniProtKB)
Alt. Names/Synonyms: DKFZp779G0847; MGC48327; N-WASP; Neural Wiskott-Aldrich syndrome protein; NWASP; WASL; Wiskott-Aldrich syndrome gene-like; Wiskott-Aldrich syndrome gene-like protein; Wiskott-Aldrich syndrome-like
Gene Symbols: WASL
Molecular weight: 54,827 Da
Basal Isoelectric point: 8.05  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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N-WASP

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene