N-WASP Regulates actin polymerization by stimulating the actin- nucleating activity of the Arp2/3 complex. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression. Binds actin and the Arp2/3 complex. Interacts with CDC42. Binds to SH3 domains of GRB2. Interacts with the C-terminal SH3 domain of DNMBP. Interacts with SNX9. Interacts with the WW domains of PRPF40A/FBP11. Interacts with PTK2/FAK1. Interacts with NOSTRIN. Interacts with Shigella flexneri protein IcsA. The interaction with IcsA enhances the affinity of WASL for Arp2/3, thus assembling a tight complex which has maximal activity in actin assembly. Interacts with E.coli effector protein EspF(U). Identified in a complex containing at least WASL, BAIAP2L1 and E.coli EspF(U). Binds to TNK2. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 7q31.32
Cellular Component:  actin cap; actin cytoskeleton; cytoplasmic vesicle; cytosol; endocytic vesicle membrane; lamellipodium; nucleus; plasma membrane
Molecular Function:  GTPase regulator activity; protein binding
Biological Process:  actin filament polymerization; actin polymerization or depolymerization; cell division; cellular protein-containing complex localization; dendritic spine morphogenesis; ephrin receptor signaling pathway; Fc-gamma receptor signaling pathway involved in phagocytosis; membrane organization; negative regulation of lymphocyte migration; negative regulation of membrane tubulation; positive regulation of Arp2/3 complex-mediated actin nucleation; positive regulation of clathrin-dependent endocytosis; positive regulation of filopodium assembly; positive regulation of transcription by RNA polymerase II; protein-containing complex assembly; regulation of nitric-oxide synthase activity; regulation of protein localization; response to bacterium; spindle localization; vesicle budding from membrane; vesicle organization; vesicle transport along actin filament
Reference #:  O00401 (UniProtKB)
Alt. Names/Synonyms: DKFZp779G0847; MGC48327; N-WASP; Neural Wiskott-Aldrich syndrome protein; NWASP; WASL; Wiskott-Aldrich syndrome gene-like; Wiskott-Aldrich syndrome gene-like protein; Wiskott-Aldrich syndrome-like
Gene Symbols: WASL
Molecular weight: 54,827 Da
Basal Isoelectric point: 8.05  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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