mGluR3 G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity. Belongs to the G-protein coupled receptor 3 family. Detected in brain cortex, thalamus, subthalamic nucleus, substantia nigra, hypothalamus, hippocampus, corpus callosum, caudate nucleus and amygdala. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of human Ortholog: 7q21.11-q21.12
Cellular Component:  astrocyte projection; axon; dendritic spine; glutamatergic synapse; plasma membrane; postsynaptic density; postsynaptic membrane; presynaptic membrane
Molecular Function:  calcium channel regulator activity; G protein-coupled receptor activity; glutamate receptor activity; group II metabotropic glutamate receptor activity; scaffold protein binding
Biological Process:  adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway; chemical synaptic transmission; G protein-coupled glutamate receptor signaling pathway; gene expression; negative regulation of adenylate cyclase activity; postsynaptic modulation of chemical synaptic transmission; regulation of synaptic transmission, glutamatergic
Reference #:  Q14832 (UniProtKB)
Alt. Names/Synonyms: GLUR3; glutamate metabotropic receptor 3; glutamate receptor, metabotropic 3; GPRC1C; GRM3; Metabotropic glutamate receptor 3; mGlu3; MGLUR3
Gene Symbols: GRM3
Molecular weight: 98,879 Da
Basal Isoelectric point: 7.93  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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