mGluR3 metabotropic glutamate receptor 3, a G-protein coupled receptor for glutamate. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 7q21.11-q21.12
Cellular Component:  axon; dendritic spine; glutamatergic synapse; integral component of postsynaptic membrane; integral component of presynaptic membrane; plasma membrane; postsynaptic density
Molecular Function:  calcium channel regulator activity; G protein-coupled receptor activity; glutamate receptor activity
Biological Process:  adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway; chemical synaptic transmission; G protein-coupled receptor signaling pathway; negative regulation of adenylate cyclase activity
Reference #:  Q14832 (UniProtKB)
Alt. Names/Synonyms: GLUR3; glutamate metabotropic receptor 3; glutamate receptor, metabotropic 3; GPRC1C; GRM3; Metabotropic glutamate receptor 3; mGlu3; MGLUR3
Gene Symbols: GRM3
Molecular weight: 98,879 Da
Basal Isoelectric point: 7.93  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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