mGluR3 G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity. Belongs to the G-protein coupled receptor 3 family. Detected in brain cortex, thalamus, subthalamic nucleus, substantia nigra, hypothalamus, hippocampus, corpus callosum, caudate nucleus and amygdala. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of mouse Ortholog: 5|5 A1
Cellular Component:  astrocyte projection; axon; dendritic spine; glutamatergic synapse; membrane; neuron projection; plasma membrane; postsynaptic density; postsynaptic membrane; presynaptic active zone; presynaptic membrane
Molecular Function:  calcium channel regulator activity; G protein-coupled receptor activity; group II metabotropic glutamate receptor activity; scaffold protein binding
Biological Process:  cellular response to stress; G protein-coupled glutamate receptor signaling pathway; G protein-coupled receptor signaling pathway; gene expression; modulation of chemical synaptic transmission; postsynaptic modulation of chemical synaptic transmission; regulation of sensory perception of pain; regulation of synaptic transmission, glutamatergic; sensory perception of pain; signal transduction; synaptic transmission, glutamatergic
Reference #:  Q9QYS2 (UniProtKB)
Alt. Names/Synonyms: 0710001G23Rik; G protein-coupled receptor, family C, group 1, member C; glutamate receptor, metabotropic 3; Gprc; Gprc1c; Grm3; Metabotropic glutamate receptor 3; mGlu; mGlu3; Mglur3
Gene Symbols: Grm3
Molecular weight: 99,114 Da
Basal Isoelectric point: 8.05  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein