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GABRB1
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB1 sub-subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel |
| Chromosomal Location of mouse Ortholog: 5 C3.2|5 38.18 cM |
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Cellular Component:
chloride channel complex; dendrite; GABA-A receptor complex; GABA-ergic synapse; membrane; neuron projection; nuclear envelope; plasma membrane; postsynaptic membrane; postsynaptic specialization membrane; presynaptic active zone membrane; receptor complex; Schaffer collateral - CA1 synapse; synapse
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Molecular Function:
chloride channel activity; extracellular ligand-gated monoatomic ion channel activity; G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential; GABA receptor binding; GABA-A receptor activity; GABA-gated chloride ion channel activity; ligand-gated monoatomic ion channel activity; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential; monoatomic anion channel activity; monoatomic ion channel activity; neurotransmitter receptor activity; transmembrane signaling receptor activity; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
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Biological Process:
cellular response to histamine; chemical synaptic transmission; chloride transmembrane transport; chloride transport; gamma-aminobutyric acid signaling pathway; monoatomic ion transmembrane transport; monoatomic ion transport; nervous system process; regulation of membrane potential; response to toxic substance; signal transduction
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Reference #:
P50571
(UniProtKB)
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Alt. Names/Synonyms: AW061132; B230208N19Rik; GABA(A) receptor subunit beta-1; Gabrb; Gabrb-1; Gabrb1; gamma-aminobutyric acid (GABA) A receptor, subunit beta 1; gamma-aminobutyric acid (GABA-A) receptor, subunit beta 1; Gamma-aminobutyric acid receptor subunit beta-1; GBRB1; OTTMUSP00000029066
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Gene Symbols: Gabrb1
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Molecular weight:
54,100 Da
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Basal Isoelectric point:
8.9
Predict pI for various phosphorylation states
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