GABRB1 Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB1 sub-subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel
Chromosomal Location of mouse Ortholog: 5 C3.2|5 38.18 cM
Cellular Component:  cell junction; chloride channel complex; cytoplasm; dendrite; GABA-A receptor complex; GABA-ergic synapse; integral component of membrane; integral component of plasma membrane; membrane; neuron projection; nuclear envelope; nucleus; plasma membrane; postsynaptic membrane; receptor complex; synapse
Molecular Function:  anion channel activity; chloride channel activity; GABA receptor binding; GABA-A receptor activity; GABA-gated chloride ion channel activity; ion channel activity; ligand-gated ion channel activity; transmembrane signaling receptor activity; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
Biological Process:  cellular response to histamine; chemical synaptic transmission; chloride transmembrane transport; chloride transport; gamma-aminobutyric acid signaling pathway; ion transmembrane transport; ion transport; nervous system process; regulation of membrane potential; response to toxic substance; signal transduction
Reference #:  P50571 (UniProtKB)
Alt. Names/Synonyms: AW061132; B230208N19Rik; GABA(A) receptor subunit beta-1; Gabrb; Gabrb-1; Gabrb1; gamma-aminobutyric acid (GABA) A receptor, subunit beta 1; gamma-aminobutyric acid (GABA-A) receptor, subunit beta 1; Gamma-aminobutyric acid receptor subunit beta-1; GBRB1; OTTMUSP00000029066
Gene Symbols: Gabrb1
Molecular weight: 54,100 Da
Basal Isoelectric point: 8.9  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene